Preparation of adsorbents for the removal of endotoxin.

Abstract

By using the agar beads as the support, L-lysine as the ligand, three kinds of absorbents with different spacers for removal of endotoxin were prepared. The adsorption capacity of three adsorbents was compared. Among them, Ag3, with L-lysine ligand and hexamethylendiamine as the spacer, was the best in adsorption capacity and was selected for hemoperfusion on rabbits. The results showed the level of endotoxin in endotoxemia rabbit after hemoperfusion was near normal level. The clearance percentage of endotoxin was 73.6%

• Authors: Guanghui Hou, Tao Liu, Huiyan Wang, Guoqi Fu, Zhi Yuan, Bin Liu, Lanju Sun, Jie Fang, Donghua Li, Qi Qiu
• Journal: Artificial cells, blood substitutes, and immobilization biotechnology (Artif Cells Blood Substit Immobil Biotechnol) Vol. 33 Issue 2 Pg. 227-37 ( 2005) ISSN: 1073-1199 [Print] England
• PMID: 15960082 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Endotoxins
• Ligands
• Lysine

Topics

• Adsorption
• Animals
• Endotoxemia (therapy)
• Endotoxins (isolation & purification)
• Hemoperfusion (methods)
• Ligands
• Lysine
• Rabbits