Abstract | BACKGROUND AND AIMS:
alpha-Naphthylisothiocyanate (ANIT) is known to cause cholestasis due to injury of the bile duct epithelial cells. The aim of the present study was to examine the effect of a single dose of ANIT on the biliary excretion of various cholephilic compounds and on the amount of canalicular transporters. METHODS: RESULTS: CONCLUSIONS: These findings support canalicular transporters having little effect on the marked impairment of biliary excretion of cholephilic compounds in ANIT-induced cholestasis.
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Authors | Hiroko Kurihara, Naoyo Sano, Hajime Takikawa |
Journal | Journal of gastroenterology and hepatology
(J Gastroenterol Hepatol)
Vol. 20
Issue 7
Pg. 1069-74
(Jul 2005)
ISSN: 0815-9319 [Print] Australia |
PMID | 15955216
(Publication Type: Comparative Study, Journal Article)
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Copyright | (c) 2005 Blackwell Publishing Asia Pty Ltd. |
Chemical References |
- Anions
- Antineoplastic Agents, Phytogenic
- Bile Acids and Salts
- Cholagogues and Choleretics
- 1-Naphthylisothiocyanate
- Taurocholic Acid
- Vinblastine
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Topics |
- 1-Naphthylisothiocyanate
(administration & dosage, toxicity)
- Administration, Oral
- Animals
- Anions
- Antineoplastic Agents, Phytogenic
(pharmacokinetics)
- Bile
(metabolism)
- Bile Acids and Salts
(metabolism)
- Biological Transport
(drug effects)
- Cholagogues and Choleretics
(pharmacokinetics)
- Cholestasis
(chemically induced, metabolism)
- Disease Models, Animal
- Male
- Rats
- Rats, Sprague-Dawley
- Taurocholic Acid
(pharmacokinetics)
- Vinblastine
(pharmacokinetics)
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