Extended release amoxicillin/clavulanate: optimizing a product for respiratory infections based on pharmacodynamic principles.

Abstract

Acute bacterial respiratory tract infections cause a great deal of human morbidity and mortality. Treatment guidelines for these infections include macrolides, doxycycline, beta-lactams and beta-lactam/beta-lactamase inhibitor combinations such as amoxicillin/clavulanic acid to provide coverage for the common respiratory pathogens, including penicillin and macrolide nonsusceptible Streptococcus pneumoniae, as well as beta-lactamase-producing Haemophilus influenzae and Moraxella catarrhalis. In response to recent guidelines recommending higher dose amoxicillin to extend coverage to a higher percentage of S. pneumoniae, a new formulation of amoxicillin/clavulanic acid was developed. This formulation includes a higher amoxicillin dose, with part of the amoxicillin dose being in an extended release formulation, without increasing the clavulanate dose, for twice-daily oral treatment of these infections. Clinical studies of community-acquired pneumonia and acute rhinosinusitis have shown that the new formulation is well tolerated and highly efficacious, with clinical outcomes equivalent to comparators.

• Authors: Michael R Jacobs
• Journal: Expert review of anti-infective therapy (Expert Rev Anti Infect Ther) Vol. 3 Issue 3 Pg. 353-60 (Jun 2005) ISSN: 1744-8336 [Electronic] England
• PMID: 15954852 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Review)

Chemical References

• Anti-Bacterial Agents
• Delayed-Action Preparations
• Amoxicillin-Potassium Clavulanate Combination

Topics

• Amoxicillin-Potassium Clavulanate Combination (administration & dosage, pharmacokinetics, therapeutic use)
• Anti-Bacterial Agents (administration & dosage, pharmacokinetics, therapeutic use)
• Delayed-Action Preparations
• Humans
• Practice Guidelines as Topic
• Respiratory Tract Infections (drug therapy, microbiology)