Abstract | BACKGROUND: Digital fibromas are common benign acral tumors typically reported as angiofibromas (AFs) or acquired digital fibrokeratomas (ADFs). Cellular variants are not well recognized. METHODS: RESULTS: The 14 cellular digital fibromas showed intersecting fascicles of thin delicate bland spindle cells in the superficial reticular dermis with a fibrotic-to-slight myxoid stroma. The spindle cells in all cases stained strongly for CD34, and only scattered stromal cells stained for Factor XIIIa. Five tested cases were negative for EMA and S100 protein. The digital AFs, fibrokeratomas, and dermatofibromas stained predominately for Factor XIIIa, with no or minimal staining for CD34. CONCLUSIONS: These findings suggest that a subset of digital fibromas is characterized by a dense cellular proliferation of CD34-positive spindle cells. Awareness of this variant of digital fibroma and its staining pattern is critical in preventing misdiagnosis as dermatofibrosarcoma protuberans, particularly in superficial biopsies.
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Authors | Jennifer M McNiff, Antonio Subtil, Shawn E Cowper, Rossitza Lazova, Earl J Glusac |
Journal | Journal of cutaneous pathology
(J Cutan Pathol)
Vol. 32
Issue 6
Pg. 413-8
(Jul 2005)
ISSN: 0303-6987 [Print] United States |
PMID | 15953374
(Publication Type: Comparative Study, Journal Article)
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Chemical References |
- Antigens, CD34
- Biomarkers, Tumor
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Topics |
- Adult
- Aged
- Aged, 80 and over
- Antigens, CD34
(metabolism)
- Biomarkers, Tumor
(analysis)
- Dermatofibrosarcoma
(metabolism, pathology)
- Diagnosis, Differential
- Female
- Fibroma
(metabolism, pathology)
- Fingers
(pathology)
- Humans
- Immunohistochemistry
- Male
- Middle Aged
- Neoplasms, Connective Tissue
(metabolism, pathology)
- Skin Neoplasms
(metabolism, pathology)
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