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Suppression of estrogen-withdrawal headache with extended transdermal contraception.

Abstract
A randomized clinical trial was conducted with 239 women at nine clinical research sites to compare bleeding profile, headache frequency, and subject satisfaction with the transdermal contraceptive, ORTHO EVRA (norelgestromin/ethinyl estradiol transdermal system) used in an extended regimen (84 days) with a traditional, 28-day cyclic regimen. In a majority of women studied, compared with cyclic use, extended use of transdermal norelgestromin/ethinyl estradiol delayed menses and reduced the total incidence of mean headache days during the hormone-free interval.
AuthorsKatherine D LaGuardia, Alan C Fisher, James D Bainbridge, John M LoCoco, Andrew J Friedman
JournalFertility and sterility (Fertil Steril) Vol. 83 Issue 6 Pg. 1875-7 (Jun 2005) ISSN: 1556-5653 [Electronic] United States
PMID15950671 (Publication Type: Comparative Study, Journal Article, Multicenter Study, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
Chemical References
  • Delayed-Action Preparations
  • Drug Combinations
  • Oximes
  • Norgestrel
  • Ethisterone
  • norelgestromin
Topics
  • Administration, Cutaneous
  • Adolescent
  • Adult
  • Delayed-Action Preparations
  • Drug Combinations
  • Ethisterone (administration & dosage, analogs & derivatives)
  • Female
  • Headache (drug therapy, prevention & control)
  • Humans
  • Middle Aged
  • Norgestrel (administration & dosage, analogs & derivatives)
  • Oximes (administration & dosage)
  • Substance Withdrawal Syndrome (drug therapy, prevention & control)
  • Time Factors

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