Abstract | BACKGROUND: METHODS: Sixteen patients with bronchial hyper-reactivity (PD20 FEV1 < 200 microg) were randomly assigned to three methacholine challenge tests at a 48 to 72 hours interval apart. In the first test IB was inhaled before the challenge (pre-IB), in the second IB was administered soon after the PD20 FEV1 (post-IB), and in the third no treatment was given (control). RESULTS: The pre-IB PD20 FEV1 (695 +/- 587.6 microg) was significantly greater (p < 0.0001) than that of post-IB (82.2 +/- 49.18 microg) and of control (73.9 +/- 41.8 microg). The dose response slope (DRS) (decline percentage of FEV1/cumulative methacholine dose), in pre-IB was greatly lower (p < 0.0001) than that in post-IB and in control. During the bronchospasm relief phase, the increase of FEV1 measured after 5, 10, 15, 30 and 60 minutes from the PD20 FEV1 was significantly greater in post-IB (p < 0.05) compared with the other two conditions. Conversely, the recovery slope (RS) (increase percentage of FEV1 at 60 minutes after PD20 FEV1 x cumulative methacholine dose) was significantly more efficient (p < 0.001) in pre-IB than in post-IB and in control. CONCLUSION:
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Authors | B Sposato, S Mariotta, A Ricci, P Bruno, C Terzano, F Mannino |
Journal | European review for medical and pharmacological sciences
(Eur Rev Med Pharmacol Sci)
2005 Mar-Apr
Vol. 9
Issue 2
Pg. 117-23
ISSN: 1128-3602 [Print] Italy |
PMID | 15945501
(Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial)
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Chemical References |
- Bronchoconstrictor Agents
- Bronchodilator Agents
- Methacholine Chloride
- Ipratropium
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Topics |
- Administration, Inhalation
- Adult
- Asthma
(complications)
- Bronchial Hyperreactivity
(complications)
- Bronchial Provocation Tests
- Bronchial Spasm
(etiology, prevention & control)
- Bronchoconstrictor Agents
(administration & dosage)
- Bronchodilator Agents
(administration & dosage, therapeutic use)
- Female
- Forced Expiratory Volume
(drug effects)
- Humans
- Ipratropium
(administration & dosage, therapeutic use)
- Male
- Methacholine Chloride
(administration & dosage)
- Recovery of Function
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