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Cellular distribution of growth hormone-releasing hormone receptor in human reproductive system and breast and prostate cancers.

Abstract
Growth hormone releasing hormone receptor (GHRH-R) mRNA and protein was first localized to the anterior pituitary gland, consequent with the action of its ligand on GH synthesis and release. Subsequent studies found GHRH-R also expressed in the hypothalamus and in systemic tissues including those of the reproductive system. In the present work, we studied the distribution of GHRH-R in human reproductive system of males and females by immunohistochemical method. GHRH-R immunostaining was localized in male reproductive system: Leydig cells, Sertoli and basal germ cells of the seminiferous tubules and prostate secretory cells. GHRH-R immunostaining was also demonstrated in the ovary: oocytes, follicular cells, granulosa, thecal and corpus luteum cells. Endometrial glands, placenta and normal mammary glands also showed GHRH-R immunostaining. Our results demonstrate the localization of GHRH-R in the reproductive system, which may mediate the direct action of GHRH in these tissues. Moreover, GHRH-R was demonstrated in prostate and breast carcinomas, opening a variety of possibilities for the use of GHRH antagonists in the treatment of prostatic and mammary tumors.
AuthorsR Gallego, E Pintos, T García-Caballero, K Raghay, L Boulanger, A Beiras, P Gaudreau, G Morel
JournalHistology and histopathology (Histol Histopathol) Vol. 20 Issue 3 Pg. 697-706 (07 2005) ISSN: 0213-3911 [Print] Spain
PMID15944917 (Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • RNA, Messenger
  • Receptors, Neuropeptide
  • Receptors, Pituitary Hormone-Regulating Hormone
  • somatotropin releasing hormone receptor
Topics
  • Adenocarcinoma (genetics, metabolism)
  • Breast Neoplasms (genetics, metabolism)
  • Female
  • Humans
  • Immunohistochemistry
  • In Situ Hybridization
  • Male
  • Mammary Glands, Human (metabolism)
  • Ovary (metabolism)
  • Placenta (metabolism)
  • Pregnancy
  • Prostatic Neoplasms (genetics, metabolism)
  • RNA, Messenger (genetics, metabolism)
  • Receptors, Neuropeptide (genetics, metabolism)
  • Receptors, Pituitary Hormone-Regulating Hormone (genetics, metabolism)
  • Testis (metabolism)
  • Uterus (metabolism)

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