Abstract |
Growth hormone releasing hormone receptor (GHRH-R) mRNA and protein was first localized to the anterior pituitary gland, consequent with the action of its ligand on GH synthesis and release. Subsequent studies found GHRH-R also expressed in the hypothalamus and in systemic tissues including those of the reproductive system. In the present work, we studied the distribution of GHRH-R in human reproductive system of males and females by immunohistochemical method. GHRH-R immunostaining was localized in male reproductive system: Leydig cells, Sertoli and basal germ cells of the seminiferous tubules and prostate secretory cells. GHRH-R immunostaining was also demonstrated in the ovary: oocytes, follicular cells, granulosa, thecal and corpus luteum cells. Endometrial glands, placenta and normal mammary glands also showed GHRH-R immunostaining. Our results demonstrate the localization of GHRH-R in the reproductive system, which may mediate the direct action of GHRH in these tissues. Moreover, GHRH-R was demonstrated in prostate and breast carcinomas, opening a variety of possibilities for the use of GHRH antagonists in the treatment of prostatic and mammary tumors.
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Authors | R Gallego, E Pintos, T García-Caballero, K Raghay, L Boulanger, A Beiras, P Gaudreau, G Morel |
Journal | Histology and histopathology
(Histol Histopathol)
Vol. 20
Issue 3
Pg. 697-706
(07 2005)
ISSN: 0213-3911 [Print] Spain |
PMID | 15944917
(Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- RNA, Messenger
- Receptors, Neuropeptide
- Receptors, Pituitary Hormone-Regulating Hormone
- somatotropin releasing hormone receptor
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Topics |
- Adenocarcinoma
(genetics, metabolism)
- Breast Neoplasms
(genetics, metabolism)
- Female
- Humans
- Immunohistochemistry
- In Situ Hybridization
- Male
- Mammary Glands, Human
(metabolism)
- Ovary
(metabolism)
- Placenta
(metabolism)
- Pregnancy
- Prostatic Neoplasms
(genetics, metabolism)
- RNA, Messenger
(genetics, metabolism)
- Receptors, Neuropeptide
(genetics, metabolism)
- Receptors, Pituitary Hormone-Regulating Hormone
(genetics, metabolism)
- Testis
(metabolism)
- Uterus
(metabolism)
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