Usefulness of famotidine in functional dyspepsia patient treatment: comparison among prokinetic, acid suppression and antianxiety therapies.

Abstract

BACKGROUND:

The treatment of functional dyspepsia is controversial.

AIM:

The purpose of this paper is to clarify the initial effect of prokinetic, acid suppression and antianxiety treatment for functional dyspepsia patients.

PATIENTS AND METHODS:

Sixty-four functional dyspepsia patients without Helicobacter pylori infection were randomly assigned to 15 mg/day of mosapride, 40 mg/day of famotidine, or 30 mg/day of tandospirone during an 8-week treatment. Individual functional dyspepsia symptoms were evaluated with 4 cm visual analogue scale before and at 2, 4 and 8 weeks after treatment.

RESULTS:

Among 64 enrolled patients, 62 completed the study. Within 2 weeks, visual analogue scale score in the mosapride-treated group decreased from 2.29 +/-0.14 to 1.57 +/- 0.20; in the famotidine from 2.04 +/- 0.16 to 1.09 +/- 0.12 (mean +/- S.E.). Therefore, there were significant improvements of functional dyspepsia symptoms in mosapride- and famotidine-treated patients (P <0.01). Furthermore, famotidine was significantly more effective than mosapride (P < 0.05). On the contrary, visual analogue scale score in the tandospirone therapy was 2.23 +/- 0.20 and 2.13 +/- 0.22 before and at 2 weeks, respectively, without any significant improvement.

CONCLUSIONS:

A treatment regimen of famotidine at 40 mg/day had a significant favourable effect on the clinical outcome in functional dyspepsia patients.

• Authors: H Seno, H Nakase, T Chiba
• Journal: Alimentary pharmacology & therapeutics (Aliment Pharmacol Ther) Vol. 21 Suppl 2 Pg. 32-6 (Jun 2005) ISSN: 0269-2813 [Print] England
• PMID: 15943844 (Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial)

Chemical References

• Anti-Anxiety Agents
• Benzamides
• Gastrointestinal Agents
• Isoindoles
• Morpholines
• Piperazines
• Pyrimidines
• Serotonin Receptor Agonists
• tandospirone
• Famotidine
• mosapride

Topics

• Anti-Anxiety Agents (therapeutic use)
• Anxiety Disorders (drug therapy)
• Benzamides (therapeutic use)
• Drug Therapy, Combination
• Dyspepsia (drug therapy)
• Famotidine (therapeutic use)
• Female
• Gastrointestinal Agents (therapeutic use)
• Humans
• Isoindoles
• Male
• Middle Aged
• Morpholines (therapeutic use)
• Piperazines (therapeutic use)
• Pyrimidines (therapeutic use)
• Serotonin Receptor Agonists (therapeutic use)