Large cell calcifying Sertoli cell tumor of the testis: comparative immunohistochemical study with Leydig cell tumor.

Abstract

Large cell calcifying Sertoli cell tumor is a rare type of testicular tumor. Reported herein is a Japanese patient with this tumor not associated with Carney's complex. An 11-year-old boy was admitted to hospital because of left testicular enlargement, and radical orchiectomy was performed. Macroscopically, the tumor was well circumscribed and had a maximum diameter of approximately 2 cm. The cut surface showed a yellow-white solid mass. Histologically, the tumor was composed of large neoplastic cells with abundant eosinophilic cytoplasm with a tubular, trabecular, and solid arrangement and loose myxoid stroma with irregularly shaped calcification. Immunohistochemically, the tumor cells were positive for vimentin, S-100 protein, calretinin, inhibin-alpha, melan-A, and CD10, and type IV collagen and laminin were observed in the extracellular matrix around the tumor cells. The distributions of melan-A, CD10, and mitochondria were characteristically patchy; in contrast, they were diffusely distributed in the cytoplasm in a control case of Leydig cell tumor. The differences in immunostaining patterns for melan-A, CD10, and mitochondria as well as positivity for S-100 protein-beta might be useful diagnostic hallmarks of large cell calcifying Sertoli cell tumor for discrimination from Leydig cell tumor.

• Authors: Katsuaki Sato, Yoshimichi Ueda, Aya Sakurai, Yoshimaro Ishikawa, Shin-Ya Okamoto, Hiromichi Ikawa, Shogo Katsuda
• Journal: Pathology international (Pathol Int) Vol. 55 Issue 6 Pg. 366-71 (Jun 2005) ISSN: 1320-5463 [Print] Australia
• PMID: 15943795 (Publication Type: Case Reports, Comparative Study, Journal Article)

Chemical References

• Antigens, Neoplasm
• CALB2 protein, human
• Calbindin 2
• Collagen Type V
• MART-1 Antigen
• MLANA protein, human
• Neoplasm Proteins
• S100 Calcium Binding Protein G
• S100 Proteins
• Vimentin
• inhibin-alpha subunit
• Inhibins
• Neprilysin

Topics

• Antigens, Neoplasm
• Calbindin 2
• Calcinosis (pathology)
• Child
• Collagen Type V (analysis)
• Diagnosis, Differential
• Humans
• Immunohistochemistry
• Inhibins (analysis)
• MART-1 Antigen
• Male
• Microscopy, Electron
• Neoplasm Proteins (analysis)
• Neprilysin (analysis)
• S100 Calcium Binding Protein G (analysis)
• S100 Proteins (analysis)
• Sertoli Cell Tumor (metabolism, pathology)
• Testicular Neoplasms (metabolism, pathology)
• Testis (chemistry, pathology, ultrastructure)
• Vimentin (analysis)