Abstract | BACKGROUND: Inter-individual variation in the severity of pneumoconiosis has been described, even with the same environmental exposure. We hypothesized that TNF-alpha promoter polymorphisms associate with lung responses to environmental exposure in coal worker's pneumoconiosis (CWP) patients. METHODS: We examined polymorphisms at -238, -308, and -376 in 124 patients with CWP who had similar dust exposure history and in 122 non-exposed controls. CWP patients were divided into two groups: (1) nodular CWP (n = 84); (2) progressive massive fibrosis (PMF) (n = 44). RESULTS: The -308 A allele frequency was higher in patients with CWP compared to controls (6.35% and 2.05%, P < 0.01). It was also higher in patients with nodular CWP compared to PMF (P < 0.05). Logistic regression analysis revealed that patients with the -308 A allele were 3.8 times (P = 0.036) and those with smoking habit were 2.3 times (P < 0.002) more likely to have nodular CWP than PMF. CONCLUSION: TNF-alpha-308 A allele might interact with smoking to enhance susceptibility to nodular CWP.
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Authors | Xin-Tao Wang, Yoshinori Ohtsuka, Kiyonobu Kimura, Miho Muroi, Takashi Ishida, Junpei Saito, Mitsuru Munakata |
Journal | American journal of industrial medicine
(Am J Ind Med)
Vol. 48
Issue 1
Pg. 24-9
(Jul 2005)
ISSN: 0271-3586 [Print] United States |
PMID | 15940715
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | Published 2005 Wiley-Liss, Inc. |
Chemical References |
- Coal
- Tumor Necrosis Factor-alpha
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Topics |
- Aged
- Alleles
- Case-Control Studies
- Coal
- Disease Susceptibility
- Humans
- Japan
(epidemiology)
- Male
- Middle Aged
- Mining
- Occupational Exposure
- Pneumoconiosis
(epidemiology, genetics)
- Polymorphism, Genetic
- Polymorphism, Restriction Fragment Length
- Tumor Necrosis Factor-alpha
(genetics)
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