Abstract | BACKGROUND: METHODS: Right-handed patients experiencing auditory hallucinations at least 5 times per day were randomly allocated to receive either rTMS or sham stimulation. A total of 132 minutes of rTMS was administered over 9 days at 90% motor threshold using a double-masked, sham-controlled, parallel design. RESULTS:
Hallucination Change Score was more improved for rTMS relative to sham stimulation (p = .008) as was the Clinical Global Impressions Scale (p = .0004). Hallucination frequency was significantly decreased during rTMS relative to sham stimulation (p = .0014) and was a moderator of rTMS effects (p = .008). There was no evidence of neurocognitive impairment associated with rTMS. CONCLUSIONS: Left temporoparietal 1-hertz rTMS warrants further study as an intervention for auditory hallucinations. Data suggest that this intervention selectively alters neurobiological factors determining frequency of these hallucinations.
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Authors | Ralph E Hoffman, Ralitza Gueorguieva, Keith A Hawkins, Maxine Varanko, Nash N Boutros, Yu-te Wu, Kathleen Carroll, John H Krystal |
Journal | Biological psychiatry
(Biol Psychiatry)
Vol. 58
Issue 2
Pg. 97-104
(Jul 15 2005)
ISSN: 0006-3223 [Print] United States |
PMID | 15936729
(Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, Non-P.H.S., Research Support, U.S. Gov't, P.H.S.)
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Topics |
- Adult
- Double-Blind Method
- Electric Stimulation Therapy
(instrumentation, methods)
- Electromagnetic Fields
- Female
- Functional Laterality
- Hallucinations
(etiology, physiopathology, therapy)
- Humans
- Male
- Middle Aged
- Parietal Lobe
(physiopathology)
- Psychotic Disorders
(complications, physiopathology, therapy)
- Schizophrenic Psychology
- Statistics, Nonparametric
- Temporal Lobe
(physiopathology)
- Transcranial Magnetic Stimulation
(therapeutic use)
- Treatment Outcome
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