Abstract |
Previous studies showed that electroacupuncture (EA) significantly attenuates inflammatory hyperalgesia in a complete Freund's adjuvant (CFA)-induced inflammatory pain rat model. The present study demonstrates that pretreatment with Derm-sap, a selective toxin for neurons that contain mu opioid receptor (MOR), specifically decreases MOR and blocks EA anti- hyperalgesia. These data suggest that spinal MOR-containing neurons are involved in the processes by which EA produces anti- hyperalgesia.
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Authors | Rui-Xin Zhang, Linbo Wang, Bing Liu, Jian-Tian Qiao, Ke Ren, Brian M Berman, Lixing Lao |
Journal | Brain research
(Brain Res)
Vol. 1048
Issue 1-2
Pg. 235-40
(Jun 28 2005)
ISSN: 0006-8993 [Print] Netherlands |
PMID | 15922310
(Publication Type: Comparative Study, Journal Article, Research Support, N.I.H., Extramural, Research Support, U.S. Gov't, P.H.S.)
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Chemical References |
- Lectins
- Opioid Peptides
- Receptors, Opioid, delta
- Receptors, Opioid, mu
- Recombinant Fusion Proteins
- Ribosome Inactivating Proteins, Type 1
- dermorphin-saporin
- Substance P
- Freund's Adjuvant
- N-Glycosyl Hydrolases
- Saporins
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Topics |
- Analysis of Variance
- Animals
- Blotting, Western
(methods)
- Electroacupuncture
(methods)
- Freund's Adjuvant
(adverse effects)
- Hindlimb
(drug effects, innervation)
- Hyperalgesia
(etiology, therapy)
- Immunohistochemistry
(methods)
- Inflammation
(chemically induced, complications)
- Lectins
(metabolism)
- Male
- N-Glycosyl Hydrolases
- Neurons
(metabolism)
- Opioid Peptides
- Pain Measurement
(methods)
- Random Allocation
- Rats
- Rats, Sprague-Dawley
- Reaction Time
(drug effects)
- Receptors, Opioid, delta
(metabolism)
- Receptors, Opioid, mu
(metabolism)
- Recombinant Fusion Proteins
(pharmacology)
- Ribosome Inactivating Proteins, Type 1
- Saporins
- Skin
(drug effects, innervation)
- Spinal Cord
(cytology, drug effects, metabolism)
- Substance P
(metabolism)
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