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Mu opioid receptor-containing neurons mediate electroacupuncture-produced anti-hyperalgesia in rats with hind paw inflammation.

Abstract
Previous studies showed that electroacupuncture (EA) significantly attenuates inflammatory hyperalgesia in a complete Freund's adjuvant (CFA)-induced inflammatory pain rat model. The present study demonstrates that pretreatment with Derm-sap, a selective toxin for neurons that contain mu opioid receptor (MOR), specifically decreases MOR and blocks EA anti-hyperalgesia. These data suggest that spinal MOR-containing neurons are involved in the processes by which EA produces anti-hyperalgesia.
AuthorsRui-Xin Zhang, Linbo Wang, Bing Liu, Jian-Tian Qiao, Ke Ren, Brian M Berman, Lixing Lao
JournalBrain research (Brain Res) Vol. 1048 Issue 1-2 Pg. 235-40 (Jun 28 2005) ISSN: 0006-8993 [Print] Netherlands
PMID15922310 (Publication Type: Comparative Study, Journal Article, Research Support, N.I.H., Extramural, Research Support, U.S. Gov't, P.H.S.)
Chemical References
  • Lectins
  • Opioid Peptides
  • Receptors, Opioid, delta
  • Receptors, Opioid, mu
  • Recombinant Fusion Proteins
  • Ribosome Inactivating Proteins, Type 1
  • dermorphin-saporin
  • Substance P
  • Freund's Adjuvant
  • N-Glycosyl Hydrolases
  • Saporins
Topics
  • Analysis of Variance
  • Animals
  • Blotting, Western (methods)
  • Electroacupuncture (methods)
  • Freund's Adjuvant (adverse effects)
  • Hindlimb (drug effects, innervation)
  • Hyperalgesia (etiology, therapy)
  • Immunohistochemistry (methods)
  • Inflammation (chemically induced, complications)
  • Lectins (metabolism)
  • Male
  • N-Glycosyl Hydrolases
  • Neurons (metabolism)
  • Opioid Peptides
  • Pain Measurement (methods)
  • Random Allocation
  • Rats
  • Rats, Sprague-Dawley
  • Reaction Time (drug effects)
  • Receptors, Opioid, delta (metabolism)
  • Receptors, Opioid, mu (metabolism)
  • Recombinant Fusion Proteins (pharmacology)
  • Ribosome Inactivating Proteins, Type 1
  • Saporins
  • Skin (drug effects, innervation)
  • Spinal Cord (cytology, drug effects, metabolism)
  • Substance P (metabolism)

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