Plasma NT-proBNP is a potential marker of disease severity and correlates with symptoms in patients with chronic rheumatic valve disease.

A noninvasive marker of disease severity and presence of symptoms is required in patients with chronic rheumatic valve disease (RVD).
We sought to test the utility of measuring of N-terminal pro-B type natriuretic peptide (NT-proBNP) in chronic phase RVD. We also evaluated whether echocardiographic measures are interrelated with NT-proBNP levels.
The study comprised 92 patients with RVD (mean age of 40+/-14 years) and 50 age/gender-matched control subjects. Functional status was assessed. Detailed echocardiographic examination was performed and mitral valve score was estimated. Venous blood samples were taken for measuring the level of NT-proBNP.
The plasma levels of NT-proBNP rose with increasing severity of mitral valve stenosis (p<0.001), increasing severity of mitral valve score (p<0.001), increasing severity of clinical symptom (p<0.001), increasing severity of mitral regurgitation (p<0.013), presence of mitral valve calcification (p<0.001), presence of tricuspid valve stenosis (p<0.001), increasing severity of tricuspid regurgitation (p<0.011), presence of aortic stenosis (p=0.043), decreasing left ventricular ejection fraction (p<0.001), presence of left atrial thrombus (p=0.0019), and with increasing left atrium dimensions (p=0.002).
NT-proBNP levels in patients with chronic RVD are a potential marker of disease severity and correlates with symptoms.
AuthorsVedat Davutoglu, Ahmet Celik, Mehmet Aksoy, Yusuf Sezen, Serdar Soydinc, Nurullah Gunay
JournalEuropean journal of heart failure (Eur J Heart Fail) Vol. 7 Issue 4 Pg. 532-6 (Jun 2005) ISSN: 1388-9842 [Print] Netherlands
PMID15921791 (Publication Type: Journal Article)
Chemical References
  • Biomarkers
  • Peptide Fragments
  • pro-brain natriuretic peptide (1-76)
  • Natriuretic Peptide, Brain
  • Adolescent
  • Adult
  • Aged
  • Aortic Valve Insufficiency (blood)
  • Biomarkers (blood)
  • Chronic Disease
  • Heart Valve Diseases (blood, ultrasonography)
  • Humans
  • Male
  • Middle Aged
  • Mitral Valve Insufficiency (blood)
  • Natriuretic Peptide, Brain (blood)
  • Peptide Fragments (blood)
  • Rheumatic Heart Disease (blood, ultrasonography)

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