Abstract | OBJECTIVE: RESEARCH DESIGN AND METHODS: The Inter99 study is a nonpharmacological intervention study. We used baseline data and examined cross-sectional associations between carbohydrate-related dietary factors and an estimate of insulin resistance in 5,675 subjects at 30-60 years. The dietary intake was estimated from a self-administered food frequency questionnaire, and insulin resistance was estimated using the homeostasis model assessment of insulin resistance (HOMA-IR). Multiple regressions were performed with HOMA-IR as the dependent variable and carbohydrate-related factors as explanatory variables. All models were adjusted for age, sex, smoking, physical activity, total energy intake, BMI, and waist circumference. RESULTS: Intake of lactose was positively associated with HOMA-IR (P < 0.0001), whereas daily glycemic load and intake of glucose, fructose, dietary fiber, total carbohydrate, fruit, and vegetables were inversely associated with HOMA-IR (P < 0.05). Intake of dietary fiber explained the associations with daily glycemic load and total carbohydrate and attenuated the association with fruit and vegetables. No significant associations were observed for daily glycemic index or sucrose. CONCLUSIONS:
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Authors | Cathrine Lau, Kristine Faerch, Charlotte Glümer, Inge Tetens, Oluf Pedersen, Bendix Carstensen, Torben Jørgensen, Knut Borch-Johnsen, Inter99 study |
Journal | Diabetes care
(Diabetes Care)
Vol. 28
Issue 6
Pg. 1397-403
(Jun 2005)
ISSN: 0149-5992 [Print] United States |
PMID | 15920058
(Publication Type: Journal Article)
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Chemical References |
- Blood Glucose
- Dietary Carbohydrates
- Dietary Fiber
- Dietary Sucrose
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Topics |
- Adult
- Blood Glucose
(metabolism)
- Cross-Sectional Studies
- Denmark
- Dietary Carbohydrates
- Dietary Fiber
- Dietary Sucrose
- Energy Intake
- Female
- Glucose Tolerance Test
- Glycemic Index
(physiology)
- Humans
- Insulin Resistance
(physiology)
- Male
- Middle Aged
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