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Esomeprazole tablet vs omeprazole capsule in treating erosive esophagitis.

AbstractAIM:
Esomeprazole, an oral S-form of omeprazole, has been a greater acid inhibitor over omeprazole in treating acid-related diseases. Only less published data is available to confirm its efficacy for Asian people. Therefore, a perspective, double-blind, randomized comparison of esomeprazole tablets 40 mg (Nexium) vs omeprazole capsules 20 mg (Losec) in treating Chinese subjects with erosive/ulcerative reflux esophagitis (EE) was conducted.
METHODS:
A total of 48 EE patients were enrolled and randomized into two treatment groups under 8-wk therapy: 25 receiving esomeprazole, while another 23 receiving omeprazole treatment. Finally, 44 completed the whole 8-wk therapy.
RESULTS:
The difference in healing EE between two groups was 22.7% (72.7% vs 50.0%), not reaching significant value (P = 0.204). The median of the first time needed in relieving heartburn sensation was 1 d for both groups and the remission rates for heartburn on the 1st d after treatment were 77.3% and 65%, respectively (NS). The scores of various reflux relieving symptoms evaluated either by patients or by investigators were not different. Regarding drug safety, 28% of esomeprazole group and 26.1% of omeprazole group reported at least one episode of adverse effects, while constipation and skin dryness were the common side effects in both groups (NS).
CONCLUSION:
Esomeprazole 40 mg is an effective and safe drug at least comparable to omeprazole in treating Chinese EE patients.
AuthorsChih-Yen Chen, Ching-Liang Lu, Jiing-Chyuan Luo, Full-Young Chang, Shou-Dong Lee, Yung-Ling Lai
JournalWorld journal of gastroenterology (World J Gastroenterol) Vol. 11 Issue 20 Pg. 3112-7 (May 28 2005) ISSN: 1007-9327 [Print] United States
PMID15918199 (Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
Chemical References
  • Anti-Ulcer Agents
  • Capsules
  • Tablets
  • Omeprazole
  • Esomeprazole
Topics
  • Administration, Oral
  • Adult
  • Aged
  • Anti-Ulcer Agents (administration & dosage, adverse effects)
  • Capsules
  • Double-Blind Method
  • Esomeprazole
  • Esophagitis, Peptic (drug therapy)
  • Female
  • Heartburn (drug therapy)
  • Humans
  • Male
  • Middle Aged
  • Omeprazole (administration & dosage, adverse effects)
  • Prospective Studies
  • Tablets

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