Abstract |
Reduction of the expression of catenin is a crucial step in the pathogenesis, progression and prognosis of many epithelial cancers including squamous cell carcinomas (SCCs). Catenin expression in oral carcinomas was evaluated in relation to clinico-pathological features in order to determine its value as a prognostic marker. Eighty-five patients with histologically proven T1/2 squamous cell carcinoma of the oral floor who underwent surgical treatment were eligible for the study. A tissue microarray consisting of multiple representative tissue cores of each carcinoma was composed. The expression levels of alpha, beta and gamma- catenins were determined immunohistologically. Correlation between clinical features and the expression of catenin proteins was evaluated statistically using Kaplan-Meier curves, log-rank tests and chi(2)-tests. Loss of alpha-catenin expression in carcinoma of the floor of the mouth correlated significantly with poor prognosis (P=0.05). Conversely, significantly reduced rates of lymph-node metastases were observed in alpha- and beta-catenin-positive T1 and T2 SCCs. Loss of gamma-catenin expression indicated a reduced survival rate in nodal-negative tumours (P=0.02). Catenin expression in carcinomas of the floor of the mouth seems to be a predictive parameter in the prognosis of T1 and T2 SSCs.
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Authors | T Fillies, H Buerger, C Gaertner, C August, B Brandt, U Joos, R Werkmeister |
Journal | International journal of oral and maxillofacial surgery
(Int J Oral Maxillofac Surg)
Vol. 34
Issue 8
Pg. 907-11
(Dec 2005)
ISSN: 1399-0020 [Electronic] Denmark |
PMID | 15916880
(Publication Type: Journal Article)
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Chemical References |
- Biomarkers, Tumor
- Catenins
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Topics |
- Adult
- Aged
- Aged, 80 and over
- Biomarkers, Tumor
(biosynthesis)
- Carcinoma, Squamous Cell
(chemistry, metabolism, pathology)
- Catenins
(biosynthesis)
- Female
- Humans
- Kaplan-Meier Estimate
- Lymphatic Metastasis
- Male
- Middle Aged
- Mouth Floor
(pathology)
- Mouth Neoplasms
(chemistry, metabolism, pathology)
- Prognosis
- Proportional Hazards Models
- Tissue Array Analysis
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