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Catenin expression in T1/2 carcinomas of the floor of the mouth.

Abstract
Reduction of the expression of catenin is a crucial step in the pathogenesis, progression and prognosis of many epithelial cancers including squamous cell carcinomas (SCCs). Catenin expression in oral carcinomas was evaluated in relation to clinico-pathological features in order to determine its value as a prognostic marker. Eighty-five patients with histologically proven T1/2 squamous cell carcinoma of the oral floor who underwent surgical treatment were eligible for the study. A tissue microarray consisting of multiple representative tissue cores of each carcinoma was composed. The expression levels of alpha, beta and gamma-catenins were determined immunohistologically. Correlation between clinical features and the expression of catenin proteins was evaluated statistically using Kaplan-Meier curves, log-rank tests and chi(2)-tests. Loss of alpha-catenin expression in carcinoma of the floor of the mouth correlated significantly with poor prognosis (P=0.05). Conversely, significantly reduced rates of lymph-node metastases were observed in alpha- and beta-catenin-positive T1 and T2 SCCs. Loss of gamma-catenin expression indicated a reduced survival rate in nodal-negative tumours (P=0.02). Catenin expression in carcinomas of the floor of the mouth seems to be a predictive parameter in the prognosis of T1 and T2 SSCs.
AuthorsT Fillies, H Buerger, C Gaertner, C August, B Brandt, U Joos, R Werkmeister
JournalInternational journal of oral and maxillofacial surgery (Int J Oral Maxillofac Surg) Vol. 34 Issue 8 Pg. 907-11 (Dec 2005) ISSN: 1399-0020 [Electronic] Denmark
PMID15916880 (Publication Type: Journal Article)
Chemical References
  • Biomarkers, Tumor
  • Catenins
Topics
  • Adult
  • Aged
  • Aged, 80 and over
  • Biomarkers, Tumor (biosynthesis)
  • Carcinoma, Squamous Cell (chemistry, metabolism, pathology)
  • Catenins (biosynthesis)
  • Female
  • Humans
  • Kaplan-Meier Estimate
  • Lymphatic Metastasis
  • Male
  • Middle Aged
  • Mouth Floor (pathology)
  • Mouth Neoplasms (chemistry, metabolism, pathology)
  • Prognosis
  • Proportional Hazards Models
  • Tissue Array Analysis

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