Abstract | OBJECTIVE: METHODS: After obtaining Institutional Review Board approval, we identified women with recurrent leiomyosarcoma treated with temozolomide at MSKCC from 9/2001 to 9/2004. Patients were treated daily with dosages ranging from 50 to 75 mg/m(2) for 6 out of 8 weeks or for 5 days every 4 weeks with 150-300 mg/m(2) daily. All patients were evaluated at least every month for toxicity and response. We reviewed patients' charts for age at diagnosis, stage, performance status, prior treatments, temozolomide dose and schedule, best response to treatment, and treatment delays or dose reductions due to toxicity. RESULTS: Twelve patients were treated with CDD temozolomide (median age, 54 years; range, 35-72 years). All patients had previously received doxorubicin; 11 had received >/=2 previous chemotherapy regimens. One patient achieved a prolonged partial response for 4 cycles; 4 demonstrated stabilization of disease for 2-5+ cycles. Seven patients were treated with BD temozolomide (median age, 50 years; range, 43-63 years). All patients received previous doxorubicin and received >/=2 previous chemotherapy regimens. Four patients achieved stabilization of disease for 3, 5, 6, and 16 cycles, respectively. One patient achieved a near complete response for 13 cycles and continues to be followed off therapy for 10+ months. CONCLUSIONS:
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Authors | Sibyl Anderson, Carol Aghajanian |
Journal | Gynecologic oncology
(Gynecol Oncol)
Vol. 98
Issue 1
Pg. 99-103
(Jul 2005)
ISSN: 0090-8258 [Print] United States |
PMID | 15916799
(Publication Type: Case Reports, Journal Article, Review)
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Chemical References |
- Antineoplastic Agents, Alkylating
- Dacarbazine
- Temozolomide
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Topics |
- Adult
- Aged
- Antineoplastic Agents, Alkylating
(administration & dosage)
- Dacarbazine
(administration & dosage, analogs & derivatives)
- Drug Administration Schedule
- Female
- Humans
- Leiomyosarcoma
(drug therapy, pathology)
- Middle Aged
- Neoplasm Staging
- Temozolomide
- Uterine Neoplasms
(drug therapy, pathology)
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