Abstract | OBJECTIVE: To report two cases demonstrating an interaction between danazol and warfarin, resulting in the potentiation of warfarin's effect and bleeding complications. DATA SOURCES: Case reports, review articles, and studies identified by MEDLINE. STUDY SELECTION: All published English-language reports involving danazol and warfarin interactions were reviewed. DATA SYNTHESIS: CONCLUSIONS: Based on this report and other published cases, clinicians must be aware that danazol may increase the anticoagulant effect of warfarin. Patients receiving warfarin who are prescribed danazol must be monitored closely to prevent excessive anticoagulation and subsequent bleeding. Studies are needed to determine the frequency of this interaction and its underlying mechanisms.
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Authors | M L Meeks, K W Mahaffey, M D Katz |
Journal | The Annals of pharmacotherapy
(Ann Pharmacother)
Vol. 26
Issue 5
Pg. 641-2
(May 1992)
ISSN: 1060-0280 [Print] United States |
PMID | 1591422
(Publication Type: Case Reports, Journal Article)
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Chemical References |
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Topics |
- Adult
- Cerebrovascular Disorders
(drug therapy)
- Danazol
(administration & dosage, pharmacology)
- Drug Synergism
- Female
- Humans
- Middle Aged
- Prothrombin Time
- Warfarin
(administration & dosage, pharmacology)
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