Metastatic clear cell variant of hepatocellular carcinoma with an occult hepatic primary.

Abstract

Metastatic clear cell carcinomas are commonly seen in the kidney and lung. Clear cell variant of hepatocellular carcinoma is an uncommon tumour. Diagnosis is usually made by correlation of histopathology, tumour markers and immunohistochemistry, especially HepPar 1. In this unusual case of metastatic clear cell carcinoma presenting as Sister Mary Joseph's nodule, no primary evidence was observed radiologically in the liver, but the level of alfa fetoprotein was markedly elevated. Metastatic clear cell carcinoma of the liver with an occult hepatic primary was diagnosed by immunohistochemical profile of the tumour.

• Authors: Samir Shah, Sudeep Gupta, Tanuja Shet, Amita Maheshwari, Rekha Wuntkal, Kunisshery Mallath Mohandas
• Journal: Hepatobiliary & pancreatic diseases international : HBPD INT (Hepatobiliary Pancreat Dis Int) Vol. 4 Issue 2 Pg. 306-7 (May 2005) ISSN: 1499-3872 [Print] Singapore
• PMID: 15908336 (Publication Type: Case Reports, Journal Article)

Chemical References

• Biomarkers, Tumor
• alpha-Fetoproteins

Topics

• Adenocarcinoma, Clear Cell (drug therapy, pathology)
• Adult
• Antineoplastic Combined Chemotherapy Protocols (therapeutic use)
• Biomarkers, Tumor (analysis)
• Biopsy, Needle
• Carcinoma, Hepatocellular (drug therapy, pathology)
• Follow-Up Studies
• Humans
• Immunohistochemistry
• Liver Neoplasms (drug therapy, pathology)
• Male
• Neoplasm Staging
• Neoplasms, Second Primary (pathology, surgery)
• Risk Assessment
• Treatment Outcome
• alpha-Fetoproteins (analysis)