Effects of lacidipine on vascular responses in patients with coronary artery disease.

Abstract

BACKGROUND:

To evaluate the effects of the calcium channel blocker lacidipine on vascular responses, such as endothelial function and carotid intima-media thickness (IMT), and on levels of high-sensitivity C-reactive protein (hs-CRP) in patients with coronary artery disease (CAD).

METHODS:

Endothelial function was assessed by measuring the flow-mediated vasodilation (FMD) of the brachial artery and IMT was measured in the common, bifurcating, and in the internal carotid artery by using high-resolution ultrasound. The study population consisted of 96 consecutive patients [mean age 60 years, male (n) = 70] who showed at least one coronary artery narrowed by more than 50% (coronary angiography). These patients were randomly assigned to lacidipine treatment (4 mg/day, n = 48) or to a placebo (n = 48). We measured FMD, IMT, and hs-CRP prior to and after 6 months of treatment and following coronary angiography in all patients.

RESULTS:

Clinical and medical history revealed no significant differences between the groups. IMT of the common carotid artery was significantly diminished from 0.92 +/- 0.15 to 0.87 +/- 0.15 mm 6 months after treatment with lacidipine (p < 0.005). However, IMT of any region in the carotid artery did not show any significant changes in the placebo group. Endothelial function and hs-CRP levels were slightly improved (insignificant) in the lacidipine group. In the placebo group, there were no significant changes.

CONCLUSION:

Lacidipine leads to a significant reduction of the common carotid artery IMT as well as to a decrease in markers of inflammation in patients with CAD during a relatively short period (6 months).

• Authors: Jang-Ho Bae, Eberhard Bassenge, Dong-Mee Lim, Yi-Chul Synn, Ki-Young Kim, Michael Schwemmer
• Journal: International journal of cardiology (Int J Cardiol) Vol. 101 Issue 3 Pg. 377-83 (Jun 08 2005) ISSN: 0167-5273 [Print] Netherlands
• PMID: 15907404 (Publication Type: Clinical Trial, Comparative Study, Journal Article, Randomized Controlled Trial)

Chemical References

• Calcium Channel Blockers
• Dihydropyridines
• lacidipine
• C-Reactive Protein

Topics

• Blood Flow Velocity (drug effects, physiology)
• Brachial Artery (diagnostic imaging, drug effects, physiopathology)
• C-Reactive Protein (metabolism)
• Calcium Channel Blockers (administration & dosage, therapeutic use)
• Carotid Artery, Internal (diagnostic imaging, drug effects, physiopathology)
• Coronary Angiography
• Coronary Artery Disease (blood, diagnostic imaging, drug therapy)
• Dihydropyridines (administration & dosage, therapeutic use)
• Dose-Response Relationship, Drug
• Female
• Humans
• Male
• Middle Aged
• Severity of Illness Index
• Treatment Outcome
• Tunica Intima (diagnostic imaging, drug effects, physiopathology)
• Ultrasonography, Doppler
• Vasodilation (drug effects, physiology)