Use of bioelectrical impedance analysis to determine body composition changes in HIV-associated wasting.

Abstract

AIDS wasting syndrome results in loss of lean body mass and body cell mass. This 12-week, open-label study used bioelectrical impedance analysis to measure body composition changes in 24 patients with AIDS wasting syndrome receiving recombinant human growth hormone (r-hGH). The primary endpoint was percentage monthly change in body weight before/after r-hGH. Secondary endpoints included change from baseline in body composition (bioelectrical impedance analysis), isometric strength and CD4+ count. Twenty patients completed the study: r-hGH resulted in mean weight gains (+2.7%, P = 0.146), and significant increases in mean body cell mass (+8.0%, P = 0.0211), lean body mass (+4.8%, P = 0.0373) and water (+5.5%, P < 0.023). Body fat decreased throughout, but not significantly. r-hGH was generally well tolerated; the most frequent adverse events were fever (7.3%) and diarrhoea (6.3%). Thus, bioelectrical impedance analysis can detect improved body cell mass independent of changes in body weight resulting from r-hGH treatment in patients with AIDS wasting syndrome.

• Authors: Stephan Klauke, Harald Fischer, Armin Rieger, Lukas Frühauf, Schlomo Staszewski, Peter-Henning Althoff, Eilke Brigitte Helm
• Journal: International journal of STD & AIDS (Int J STD AIDS) Vol. 16 Issue 4 Pg. 307-13 (Apr 2005) ISSN: 0956-4624 [Print] England
• PMID: 15899085 (Publication Type: Clinical Trial, Journal Article, Multicenter Study)

Chemical References

• Human Growth Hormone

Topics

• Adult
• Aged
• Body Composition
• Electric Impedance
• HIV Wasting Syndrome (diagnosis, drug therapy)
• Hand Strength
• Human Growth Hormone (therapeutic use)
• Humans
• Injections, Subcutaneous
• Male
• Middle Aged