Clofazimine as elective treatment for granulomatous cheilitis.

Abstract

Cheilitis granulomatosa (CG) is a rare, idiopathic inflammatory disorder that usually affects young adults and clinically is characterized by diffuse, non-tender, soft to firm swelling of one or both lips. A variant of granulomatous cheilitis is Melkersson-Rosenthal syndrome when associated with facial paralysis and furrowed tongue. Several treatments have been used with variable success. We report 3 cases of GC treated with oral clofazimine 100 to 200 mg daily for 3 to 6 months obtaining regression of lesions in all treated cases. Hyperpigmentation and elevation of liver enzymes were observed as side effects.

• Authors: Lourdes Rodríguez Fdez-Freire, Amalia Serrano Gotarredona, Jose Bernabeu Wittel, Agueda Pulpillo Ruiz, Rocío Cabrera, Manuel Navarrete Ortega, Julián Conejo-Mir
• Journal: Journal of drugs in dermatology : JDD (J Drugs Dermatol) 2005 May-Jun Vol. 4 Issue 3 Pg. 374-7 ISSN: 1545-9616 [Print] United States
• PMID: 15898297 (Publication Type: Case Reports, Journal Article)

Chemical References

• Clofazimine

Topics

• Adult
• Aged
• Clofazimine (therapeutic use)
• Female
• Humans
• Male
• Melkersson-Rosenthal Syndrome (drug therapy, pathology)