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Treatment of chromoblastomycosis with terbinafine: experience with four cases.

AbstractBACKGROUND:
Chromoblastomycosis is a chronic subcutaneous mycosis that occurs more frequently in tropical and subtropical areas and is caused by a group of dematiaceous fungi. It is a difficult-to-treat mycosis with low cure rates and a high rate of relapses.
OBJECTIVE:
The objective of this trial is to prove the efficacy and tolerance of oral terbinafine in four cases of chromoblastomycosis.
METHODS AND RESULTS:
We included four cases of chromoblastomycosis, proved clinically and mycologically, that are presented herein; three of them caused by Fonsecaea pedrosoi and one by Phialophora verrucosa. Two had a small extension and the other two were of medium and large extension. Oral terbinafine was administered at a dose of 500 mg/day, which was reduced to half in two of the cases once an 80% improvement had been reached; in the third case the initial dose was maintained, and in the fourth case the dose was increased to 750 mg/day. Three cases reached clinical and mycological cure in a mean treatment period of 7 months, the fourth case reached a significant improvement only after 1.2 years of treatment. The medication was well tolerated; no liver alterations occurred; only one patient suffered mild dyspepsia.
CONCLUSION:
Terbinafine at 500 mg/day doses represents one of the best treatments for chromoblastomycosis due to its efficacy and excellent tolerability.
AuthorsA Bonifaz, A Saúl, V Paredes-Solis, J Araiza, L Fierro-Arias
JournalThe Journal of dermatological treatment (J Dermatolog Treat) Vol. 16 Issue 1 Pg. 47-51 (Feb 2005) ISSN: 0954-6634 [Print] England
PMID15897168 (Publication Type: Case Reports, Journal Article)
Chemical References
  • Antifungal Agents
  • Naphthalenes
  • Terbinafine
Topics
  • Administration, Oral
  • Adult
  • Aged
  • Agricultural Workers' Diseases (drug therapy)
  • Antifungal Agents (administration & dosage, therapeutic use)
  • Chromoblastomycosis (drug therapy)
  • Female
  • Humans
  • Male
  • Middle Aged
  • Naphthalenes (administration & dosage, therapeutic use)
  • Phialophora (isolation & purification)
  • Terbinafine
  • Treatment Outcome

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