Neuroglial activation in Niemann-Pick Type C mice is suppressed by intracerebral transplantation of bone marrow-derived mesenchymal stem cells.

Abstract

Glial activation is thought to play a key role in pathogenesis of neurodegenerative disorders. Here we show that direct transplantation of bone marrow-derived mesenchymal stem cells (BM-MSC) results in alleviation of inflammatory responses associated with the cerebellum of Niemann-Pick disease Type C (NP-C) model mice. Immunohistochemical examinations using glial fibrillary acidic protein (GFAP) and F4/80 antibodies revealed that BM-MSC transplantation reduced significantly both of astrocytic and microglial activations in the cerebellum of NP-C mice. Expression of macrophage colony stimulating factor (M-CSF), a microglial activator, was also considerably down-regulated by the BM-MSC transplantation. These findings suggest that BM-MSC transplantation may have potential for a therapeutic role in the treatment of NP-C and other neurodegenerative brain disorders.

• Authors: Jae-sung Bae, Shigeki Furuya, So-jeo Ahn, Seong-joon Yi, Yoshio Hirabayashi, Hee Kyung Jin
• Journal: Neuroscience letters (Neurosci Lett) Vol. 381 Issue 3 Pg. 234-6 (Jun 24 2005) ISSN: 0304-3940 [Print] Ireland
• PMID: 15896475 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Glial Fibrillary Acidic Protein

Topics

• Animals
• Brain (pathology)
• Disease Models, Animal
• Glial Fibrillary Acidic Protein (metabolism)
• Immunohistochemistry
• Macrophage Activation (physiology)
• Mesenchymal Stem Cell Transplantation
• Mice
• Mice, Transgenic
• Neuroglia (metabolism)
• Niemann-Pick Diseases (pathology, therapy)