Abstract |
Immunologic studies in relation to clinical status might help to understand the pathogenesis of subacute sclerosing panencephalitis ( SSPE) and the effect of treatment. We measured lymphocyte subsets and intracellular TNFalpha and interleukin-4 levels in peripheral blood in SSPE patients. Patients had elevated percentages of CD8+ cells compared to age-matched control children. Rapidly progressive course was associated with increased CD4+ cells. Treatment with interferons and inosiplex altered the percentage of CD3+, CD4+ and CD19+ cells. TNFalpha and interleukin-4 levels had no correlation with course or treatment. The proportions of lymphocyte subsets appear to have a role in the evolution or manifestations of SSPE, if not in the pathogenesis.
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Authors | Banu Anlar, Alev Guven, Gulsen Köse, Hamza Okur, Ozgü Kose, Omer F Aydin, Nimet Kabakus, Sakir Altunbasak, Ozlem Herguner, Mujgan Sonmez, Ayse Serdaroglu |
Journal | Journal of neuroimmunology
(J Neuroimmunol)
Vol. 163
Issue 1-2
Pg. 195-8
(Jun 2005)
ISSN: 0165-5728 [Print] Netherlands |
PMID | 15885323
(Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Tumor Necrosis Factor-alpha
- Interleukin-4
- Interferons
- Inosine Pranobex
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Topics |
- Adolescent
- Child
- Child, Preschool
- Female
- Humans
- Inosine Pranobex
(therapeutic use)
- Interferons
(therapeutic use)
- Interleukin-4
(blood)
- Lymphocyte Subsets
(immunology, metabolism)
- Male
- Subacute Sclerosing Panencephalitis
(drug therapy, immunology)
- Tumor Necrosis Factor-alpha
(metabolism)
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