Abstract | OBJECT: The JC virus is a human neurotropic polyomavirus that causes progressive multifocal leukoencephalopathy and is closely related to simian virus 40. Several recent reports have indicated a possible association between the JC virus and the development of various human brain tumors. The authors examined the presence of JC virus DNA sequences in primary brain tumors in pediatric patients to evaluate the hypothesis that particular brain tumors can arise in the pediatric population as a consequence of infection with the JC virus. METHODS: CONCLUSIONS:
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Authors | Hiroaki Okamoto, Toshihiro Mineta, Shigeo Ueda, Yukiko Nakahara, Tetsuya Shiraishi, Takashi Tamiya, Kazuo Tabuchi |
Journal | Journal of neurosurgery
(J Neurosurg)
Vol. 102
Issue 3 Suppl
Pg. 294-8
(Apr 2005)
ISSN: 0022-3085 [Print] United States |
PMID | 15881753
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Antigens, Viral, Tumor
- DNA, Viral
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Topics |
- Antigens, Viral, Tumor
(genetics)
- Astrocytoma
(pathology, virology)
- Base Sequence
- Blotting, Southern
- Brain Neoplasms
(pathology, virology)
- Cerebellar Neoplasms
(pathology, virology)
- Cerebral Ventricle Neoplasms
(pathology, virology)
- Child
- Child, Preschool
- DNA, Viral
(analysis, genetics)
- Ependymoma
(pathology, virology)
- Female
- Genome, Viral
- Humans
- Infant
- JC Virus
(genetics)
- Leukoencephalopathy, Progressive Multifocal
(pathology, virology)
- Male
- Medulloblastoma
(pathology, virology)
- Papilloma, Choroid Plexus
(pathology, virology)
- Polymerase Chain Reaction
- Supratentorial Neoplasms
(pathology, virology)
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