Abstract | PURPOSE: METHODS: A total of 61 renal units in 32 patients with hypertension were studied in two groups based on the losartan dosage (50 mg in group A and 100 mg in group B). Group A consisted of 17 patients, in whom 19 renal units had angiographically proven renal artery stenosis (>or=50%). In group B, there were 15 patients, in whom 20 renal arteries were stenotic. All of the patients underwent three renographies (baseline, captopril renography and early losartan renography). Early losartan renography was performed at 1 h after oral losartan administration in both groups. In group B, seven patients underwent additional losartan renography (late losartan) performed 3 h after oral losartan administration; these patients composed group B1. RESULTS: The sensitivities of captopril and losartan studies were 63.2% and 42% in group A, 65% and 65% in group B and 55.6% and 66.6% in group B1, respectively. CONCLUSION: From our preliminary results, we conclude that losartan is not superior to captopril renography for the detection of haemodynamically significant renal artery stenosis. However, a high dose (100 mg) of losartan provided higher sensitivity than the lower dose (50 mg). Late losartan scintigraphy provided similar diagnostic efficacy to early losartan renography.
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Authors | Emel Ceylan Günay, M Halil Oztürk, Eser Lay Ergün, Bülent Altun, Bilge Volkan Salanci, Omer Uğur, Barbaros Cil, Baki Hekimoğlu, Biray Caner |
Journal | European journal of nuclear medicine and molecular imaging
(Eur J Nucl Med Mol Imaging)
Vol. 32
Issue 9
Pg. 1064-74
(Sep 2005)
ISSN: 1619-7070 [Print] Germany |
PMID | 15875180
(Publication Type: Clinical Trial, Journal Article)
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Chemical References |
- Angiotensin-Converting Enzyme Inhibitors
- Captopril
- Losartan
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Topics |
- Adolescent
- Adult
- Aged
- Angiotensin-Converting Enzyme Inhibitors
- Captopril
(administration & dosage)
- Dose-Response Relationship, Drug
- Drug Administration Schedule
- Female
- Humans
- Losartan
(administration & dosage)
- Male
- Middle Aged
- Radioisotope Renography
(methods)
- Renal Artery Obstruction
(diagnostic imaging)
- Reproducibility of Results
- Sensitivity and Specificity
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