Abstract |
This study investigated nasal mucociliary clearance as related to nasal eosinophilia in nonallergic rhinitis patients using the technique of nasal saccharin challenge. Fifty-six consecutive patients with nonallergic rhinitis were evaluated with nasal cytology and saccharin challenge. A saccharin challenge time of greater than 25 minutes was considered abnormal. Twelve of 56 patients (21.4%) had nasal eosinophilia. Fifteen of 56 patients (26.8%) had prolonged nasal circulation times greater than 25 minutes, indicating delayed mucociliary clearance. Although 7 of 12 patients (58.3%) with nasal eosinophilia had delayed mucociliary clearance, only 8 of 44 patients (18.2%) without eosinophilia had circulation times longer than 25 minutes. The correlation of nasal eosinophilia with prolongation of the nasal circulation time is statistically significant (chi square 5.84, P = .0156). We postulate that damage to the nasal mucociliary system may be an etiologic factor for a subset of patients with nonallergic rhinitis and that this damage may be mediated by eosinophils.
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Authors | A E Davidson, S D Miller, R J Settipane, A R Ricci, D E Klein, G A Settipane |
Journal | Allergy proceedings : the official journal of regional and state allergy societies
(Allergy Proc)
1992 Mar-Apr
Vol. 13
Issue 2
Pg. 81-4
ISSN: 1046-9354 [Print] United States |
PMID | 1587470
(Publication Type: Journal Article)
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Chemical References |
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Topics |
- Adult
- Aged
- Eosinophils
(pathology)
- Female
- Humans
- Male
- Middle Aged
- Mucociliary Clearance
- Nasal Mucosa
(pathology, physiopathology)
- Rhinitis
(pathology, physiopathology)
- Saccharin
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