Abstract | AIMS/HYPOTHESIS:
Diabetic cardiomyopathy (DCM) is common in type 2 diabetes. In DCM, insulin resistance may alter cardiac substrate supply and utilisation leading to changes in myocardial metabolism and cardiac function. In rats, exposure to excessive alimentary fat, inducing a type 2 diabetic phenotype, may result in myocardial insulin resistance and cardiac functional changes resembling DCM. MATERIALS AND METHODS: Rats received high-fat (HFD) or low-fat (LFD) diets for 7 weeks. Prior to killing, insulin or saline was injected i.p. Contractile function and insulin signalling were assessed in papillary muscles and ventricular lysates, respectively. RESULTS: CONCLUSIONS/INTERPRETATION: HFD induced a hypertrophy-like cardiac phenotype, characterised by a higher basal contractile force, an impaired recovery from increased workloads and decreased insulin-mediated protection against Ca2+ overload. Cardiac dysfunction was associated with myocardial insulin resistance and phospholamban hypophosphorylation. Our data suggest that myocardial insulin resistance, resulting from exposure to excessive alimentary fat, may contribute to the pathogenesis of diabetes-related heart disease.
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Authors | D M Ouwens, C Boer, M Fodor, P de Galan, R J Heine, J A Maassen, M Diamant |
Journal | Diabetologia
(Diabetologia)
Vol. 48
Issue 6
Pg. 1229-37
(Jun 2005)
ISSN: 0012-186X [Print] Germany |
PMID | 15864533
(Publication Type: Comparative Study, Journal Article)
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Chemical References |
- Dietary Fats
- Insulin
- Triglycerides
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Topics |
- Animals
- Diet, Fat-Restricted
- Dietary Fats
(pharmacology)
- Heart
(drug effects, physiology, physiopathology)
- Heart Ventricles
- Insulin
(physiology)
- Male
- Models, Animal
- Myocardial Contraction
(drug effects, physiology)
- Papillary Muscles
(drug effects, physiology, physiopathology)
- Rats
- Rats, Wistar
- Signal Transduction
(drug effects, physiology)
- Triglycerides
(metabolism)
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