Abstract | PURPOSE: PATIENTS AND METHODS: Two hundred one patients who underwent curative resection of hepatic CRM between 1990 and 2000 were identified from a multicenter database. The CRM were analyzed for hTERT nucleolar expression by standard immunohistochemical techniques. hTERT expression and known clinicopathologic factors of survival were examined. RESULTS: With a median follow-up of 80 months, 152 patients (75.6%) had died; the 5-year overall survival was 30.7%. On univariate analysis, number of metastases greater than two (P = .0005), extrahepatic disease (P = .0054), disease-free interval less than 12 months (P = .006), carcinoembryonic antigen level greater than 200 ng/mL (P = .0071), and positive hTERT nucleolar staining (P < .0001) were associated with decreased survival. On multivariate analysis, three factors independently predicted survival: number of metastases (relative risk [RR] = 1.74; P = .0011); disease-free interval (RR = 1.70; P = .0035); and positive hTERT nucleolar staining (RR = 2.03; P < .0001). Patients with none or one of these factors had a 5-year survival rate of 48%, whereas those with two or three of these factors had a 5-year survival of 15% (P < .0001). CONCLUSION: hTERT nucleolar expression is associated with worse survival after resection of hepatic CRM. hTERT expression in conjunction with number of hepatic metastases and disease-free interval may permit more accurate prediction of survival after resection of hepatic CRM.
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Authors | Julien Dômont, Timothy M Pawlik, Valérie Boige, Mathieu Rose, Jean-Christophe Weber, Paulo M Hoff, Thomas D Brown, Daria Zorzi, Luc Morat, Jean-Pierre Pignon, Asif Rashid, Daniel Jaeck, Laure Sabatier, Dominique Elias, Thomas Tursz, Jean-Charles Soria, Jean-Nicolas Vauthey |
Journal | Journal of clinical oncology : official journal of the American Society of Clinical Oncology
(J Clin Oncol)
Vol. 23
Issue 13
Pg. 3086-93
(May 01 2005)
ISSN: 0732-183X [Print] United States |
PMID | 15860868
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- DNA-Binding Proteins
- Telomerase
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Topics |
- Adult
- Aged
- Aged, 80 and over
- Catalytic Domain
- Colorectal Neoplasms
(genetics, pathology)
- DNA-Binding Proteins
- Female
- Gene Expression Profiling
- Humans
- Immunohistochemistry
- Liver Neoplasms
(genetics, secondary, surgery)
- Male
- Middle Aged
- Multivariate Analysis
- Neoplasm Metastasis
(genetics)
- Predictive Value of Tests
- Prognosis
- Survival Analysis
- Telomerase
(genetics)
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