[Platelets and platelet microparticles glycoprotein IIb/IIIa complex in patients with unstable angina].

Abstract

UNLABELLED:

Platelet activation is known to play a key role in pathogenesis of acute coronary syndrome (ACS). Platelet activation leads to increased numbers of glycoprotein (GP) IIb/IIIa complex on the platelet membrane. On the other side antiplatelet therapy in patient with unstable angina can suppress the actions of platelet.

THE AIM:

To estimate by flow cytometry GP IIb/IIIa expression on the platelets and platelet microparticles membrane.

MATERIAL AND METHODS:

The study involved 21 patients with unstable angina, before (group B1) and after treatment (group B2). All subjects received aspirin, heparin (Clexane) and b-blocker. The control group consisted of 24 healthy subjects.

RESULTS:

Patients with unstable angina in group B1 were by 12% higher expression of GP IIb/IIIa than control group (62.6 vs 55.1%). In group B2- before treatment- the percentage of platelet expressing GP IIb/IIIa was lower (60.1%) than in the group B1. In both groups, B1 and B2, percentage of platelet microparticles expressions GP IIb/IIIa was elevated 8.5% and it was significantly higher than in the control group (5.3%).

CONCLUSIONS:

Our study show that patients with unstable angina had a higher expression GP IIb/IIIa on the platelets membrane and elevated percentage of platelet microparticles confirm platelet activation. There was no significantly different in platelet GP IIb/IIIa expression after the antiplatelet therapy in patients with unstable angina.

• Authors: Violetta Dymicka-Piekarska, Halina Kemona, Anna Butkiewicz, Jerzy Bychowski
• Journal: Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego (Pol Merkur Lekarski) Vol. 18 Issue 103 Pg. 9-12 (Jan 2005) ISSN: 1426-9686 [Print] Poland
• Vernacular Title: Kompleks glikoproteiny IIb/IIIa na płytkach krwi i mikroplytkach u chorych na niestabilna chorobe wieńcowa.
• PMID: 15859538 (Publication Type: English Abstract, Journal Article)

Chemical References

• Platelet Glycoprotein GPIIb-IIIa Complex

Topics

• Adult
• Aged
• Aged, 80 and over
• Angina, Unstable (blood, drug therapy)
• Case-Control Studies
• Female
• Flow Cytometry
• Gene Expression
• Humans
• Male
• Middle Aged
• Platelet Activation
• Platelet Glycoprotein GPIIb-IIIa Complex (metabolism)