Abstract | BACKGROUND: METHODS: We tested whether adding soy protein to a low-fat, high-fiber, Step I diet improved cardiac risk markers in 18 postmenopausal women and 14 men with hypercholesterolemia and examined whether concurrent use of HRT altered diet responsiveness. Diets were matched for macronutrient content, and all food was provided. After 3 weeks on the Step I diet, subjects were randomized to diets (6 weeks) containing 25 g/day protein isolate from soy or cow's milk, with crossover. The soy treatment contained 90 mg/day isoflavones. Lipids, vascular cell adhesion molecule-1 (VCAM-1), p-selectin, and urinary isoflavonoids were measured at the end of each diet. RESULTS: In men and HRT- women only, there were significant reductions in LDL-C (-17.3%), high-density lipoprotein cholesterol (HDL-C) (-15.3%), and triglycerides (-11.5%) during the Step I diet, and soy had no additional effects. At study entry, HRT+ women had lower LDL-C and higher triglycerides than men. Their LDL-C was unchanged, and triglycerides were significantly reduced (-15.1%) by the Step I diets. Isoflavonoid excretion was unrelated to diet response or HRT status. CONCLUSIONS: In men and HRT- women, the diets significantly lowered LDL-C, independent of soy intake. In HRT+ women, the diets improved triglycerides without lowering HDL-C.
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Authors | Sheila G West, Kirsten F Hilpert, Vijaya Juturu, Peter L Bordi, Johanna W Lampe, Shaker A Mousa, Penny M Kris-Etherton |
Journal | Journal of women's health (2002)
(J Womens Health (Larchmt))
Vol. 14
Issue 3
Pg. 253-62
(Apr 2005)
ISSN: 1540-9996 [Print] United States |
PMID | 15857272
(Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)
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Chemical References |
- Apolipoproteins
- Cholesterol, HDL
- Cholesterol, LDL
- Isoflavones
- Lipoproteins
- Soybean Proteins
- Triglycerides
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Topics |
- Apolipoproteins
(blood)
- Cholesterol, HDL
(blood)
- Cholesterol, LDL
(blood)
- Coronary Disease
(prevention & control)
- Cross-Over Studies
- Diet, Fat-Restricted
- Dose-Response Relationship, Drug
- Double-Blind Method
- Estrogen Replacement Therapy
- Female
- Humans
- Hypercholesterolemia
(drug therapy)
- Isoflavones
(therapeutic use)
- Lipoproteins
(blood)
- Male
- Middle Aged
- Phytotherapy
- Postmenopause
- Sex Factors
- Soybean Proteins
(therapeutic use)
- Time Factors
- Treatment Outcome
- Triglycerides
(blood)
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