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Therapeutic effect of D-002 (abexol) on gastric ulcer induced experimentally in rats.

Abstract
D-002 is a mixture of higher aliphatic primary alcohols isolated from beeswax, wherein triacontanol is the most abundant alcohol, with antioxidant and anti-ulcer properties. Since compounds with cytoprotective and antioxidant effects can improve healing of gastroduodenal ulcer induced by noxious agents, this work investigated the healing effect of D- 002 on acute and chronic gastric ulcers induced with indomethacin and acetic acid, respectively, in rats. Acute gastric ulcer was induced with single oral doses of indomethacin (20 mg/kg). Treatments with D-002 at 50, 100, and 200 mg/kg or vehicle were administered 3 hours after ulcer induction. Three hours later, rats were sacrificed, and the stomach was removed for quantifying the lesions. Chronic gastric ulcer was induced by 50 microL of 80% acetic acid application on the anterior serosal surface of the glandular stomach during 20 seconds. Twenty-four hours later D-002 at 50, 100, and 200 mg/kg or vehicle was administered for 5 days. At the end of the treatment, animals were fasted for 24 hours and sacrificed, the stomachs were removed, and the lesions were quantified. D-002 orally administered at 100 and 200 mg/kg acutely significantly healed gastric ulcers induced with indomethacin by 39% and 56% compared with positive controls, respectively. Also, D-002 at 200 mg/kg, but not at 50 or 100 mg/kg, administered orally for 5 days after ulcer induction exerted a significant healing effect (65.8% inhibition) in gastric ulcers induced with acetic acid. In conclusion, this work demonstrated that D-002 administered after ulcer induction induced effective healing of acute and chronic gastric ulcers provoked by, respectively, indomethacin and acetic acid.
AuthorsVivian Molina, Daisy Carbajal, Lourdes Arruzazabala, Rosa Más
JournalJournal of medicinal food (J Med Food) Vol. 8 Issue 1 Pg. 59-62 ( 2005) ISSN: 1096-620X [Print] United States
PMID15857211 (Publication Type: Journal Article)
Chemical References
  • Anti-Ulcer Agents
  • Antioxidants
  • D 002
  • Fatty Alcohols
  • Acetic Acid
  • Indomethacin
Topics
  • Acetic Acid (adverse effects, pharmacology)
  • Acute Disease
  • Administration, Oral
  • Animals
  • Anti-Ulcer Agents (therapeutic use)
  • Antioxidants (therapeutic use)
  • Chronic Disease
  • Disease Models, Animal
  • Dose-Response Relationship, Drug
  • Fatty Alcohols (therapeutic use)
  • Female
  • Indomethacin (adverse effects, pharmacology)
  • Random Allocation
  • Rats
  • Rats, Sprague-Dawley
  • Stomach Ulcer (chemically induced, drug therapy, pathology)
  • Treatment Outcome

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