Abstract | BACKGROUND: METHODS AND RESULTS: ISO 300 mg/kg was injected in rats to produce heart failure. Two months after the injection, the ISO-injected rats were divided into 4 groups (8 rats each) and treated for 4 weeks as follows: (a) vehicle; (b) celiprolol 10 mg/kg per day (BB); (c) candesartan 0.2 mg/kg per day (ARB); and (d) their combination BB+ARB. ISO significantly elevated left ventricular (LV) end-diastolic pressure, decreased peak-negative dP/dt and LV ejection fraction. BB and ARB similarly ameliorated cardiac dysfunction due to ISO, but BB+ARB were more potent than the individual therapies. Separately, ARB preserved the histological structure in LV myocardium. In contrast, BB ameliorated calcium handling, as shown by the increased ratio of SERCA2 to phospholamban protein, despite having little effect on the histology. CONCLUSION:
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Authors | Tatsuhiko Mori, Tetsuya Hayashi, Koichi Sohmiya, Nobuaki Okuda, Hiroaki Shimomura, Mamoru Ohkita, Yasuo Matsumura, Minoru Yoshiyama, Junichi Yoshikawa, Yasushi Kitaura |
Journal | Circulation journal : official journal of the Japanese Circulation Society
(Circ J)
Vol. 69
Issue 5
Pg. 596-602
(May 2005)
ISSN: 1346-9843 [Print] Japan |
PMID | 15849448
(Publication Type: Journal Article)
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Chemical References |
- Antihypertensive Agents
- Benzimidazoles
- Biphenyl Compounds
- Tetrazoles
- Celiprolol
- candesartan cilexetil
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Topics |
- Animals
- Antihypertensive Agents
(administration & dosage)
- Benzimidazoles
(administration & dosage)
- Biphenyl Compounds
(administration & dosage)
- Celiprolol
(administration & dosage)
- Disease Models, Animal
- Drug Synergism
- Drug Therapy, Combination
- Heart Failure
(drug therapy, pathology, physiopathology)
- Male
- Rats
- Rats, Sprague-Dawley
- Tetrazoles
(administration & dosage)
- Ventricular Remodeling
(drug effects)
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