Abstract |
Glycosylphosphatidylinositol ( GPI) membrane anchors of Plasmodium falciparum surface proteins are thought to be important factors contributing to malaria pathogenesis, and anti-GPI antibodies have been suggested to provide protection by neutralizing the toxic activity of GPIs. In this study, IgG responses against P. falciparum GPIs and a baculovirus recombinant MSP1p19 antigen were evaluated in two distinct groups of 70 patients each, who were hospitalized with malaria. Anti-GPI IgGs were significantly lower in patients hospitalized with confirmed cerebral malaria compared to those with mild malaria (P < 0.01) but did not discriminate for fatal outcome. In contrast, a specific marker of the anti-parasite immunity, as monitored by the anti-MSP1p19 IgG response, was similar in both cerebral and mild malaria individuals, although it was significantly lower in a subgroup with fatal outcomes. These results are consistent with a potential anti-toxin role for anti-GPI antibodies associated with protection against cerebral malaria.
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Authors | Ronald Perraut, Bacary Diatta, Laurence Marrama, Olivier Garraud, Ronan Jambou, Shirley Longacre, Gowdahalli Krishnegowda, Alioune Dieye, D Channe Gowda |
Journal | Microbes and infection
(Microbes Infect)
Vol. 7
Issue 4
Pg. 682-7
(Apr 2005)
ISSN: 1286-4579 [Print] France |
PMID | 15848275
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Antibodies, Protozoan
- Glycosylphosphatidylinositols
- Immunoglobulin G
- Merozoite Surface Protein 1
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Topics |
- Adolescent
- Adult
- Animals
- Antibodies, Protozoan
(blood)
- Case-Control Studies
- Child
- Child, Preschool
- Glycosylphosphatidylinositols
(immunology)
- Humans
- Immunoglobulin G
(blood)
- Malaria, Cerebral
(immunology, parasitology)
- Malaria, Falciparum
(immunology, parasitology)
- Merozoite Surface Protein 1
(immunology)
- Middle Aged
- Plasmodium falciparum
(immunology, pathogenicity)
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