Two-channel gastric electrical stimulation accelerates delayed gastric emptying induced by vasopressin.

Abstract

The aim of this study was to investigate the effects of two-channel gastric electrical stimulation (GES) on delayed gastric emptying, gastric dysrhythmias, and motion sickness-like symptoms induced by vasopressin. Seven dogs implanted with four pairs of gastric electrodes and a duodenal cannula were studied in four randomized sessions (saline, vasopressin, single-channel GES, and two-channel GES). The experiment in each session was conducted sequentially as follows: 30-min baseline, ingestion of a liquid meal, 30-min iv infusion of vasopressin or saline, and two 30-min postprandial recordings. In the GES sessions, GES was applied via the first pair of electrodes for single-channel GES or the first and third pairs of electrodes for two-channel GES. Gastric emptying was collected every 15 min via the cannula for a period of 90 min. Results were as follows. (1) Vasopressin induced gastric dysrhythmias, motion sickness-like symptoms, and delayed gastric emptying (P < 0.01, ANOVA). (2) GES normalized gastric dysrhythmias (P < 0.01) but showed no effects on vasopressin-induced emetic response. (3) Two-channel GES improved delayed gastric emptying induced by vasopressin. In comparison with the vasopressin session, two-channel GES, but not single-channel GES, significantly increased gastric emptying at 30 min (43.9+/-12.6 vs. 27.5+/-7.7%; P < 0.03), 60 min (75.3+/-15.1 vs. 54.0+/-17.8%; P < 0.05), and 90 min (91.6+/-9.8 vs. 80.3+/-9.0%; P < 0.05). GES with long pulses is able to normalize gastric dysrhythmias. Two-channel GES improves delayed gastric emptying induced by vasopressin.

• Authors: Gengqing Song, Xiaohua Hou, Bin Yang, Jinsong Liu, Wei Qian, Jiande D Z Chen
• Journal: Digestive diseases and sciences (Dig Dis Sci) Vol. 50 Issue 4 Pg. 662-8 (Apr 2005) ISSN: 0163-2116 [Print] United States
• PMID: 15844698 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Vasopressins

Topics

• Animals
• Dogs
• Electric Stimulation Therapy (methods)
• Gastric Emptying (drug effects)
• Male
• Motion Sickness (chemically induced, therapy)
• Periodicity
• Stomach (drug effects, physiopathology)
• Stomach Diseases (chemically induced, physiopathology, therapy)
• Time Factors
• Vasopressins (adverse effects, pharmacology)