Abstract | OBJECTIVES: METHODS: The variable number of tandem repeat (VNTR) polymorphism in the coding region of the CEL gene was studied in patients with alcoholic pancreatitis (n = 100), in alcoholics without pancreatitis (n = 52), in patients with nonalcoholic pancreatitis (n = 50), in hyperlipidemia patients (n = 96), and control subjects (n = 435). RESULTS: The frequency of the NN-type (wild-type) gene was significantly decreased in patients with alcoholic pancreatitis than in other groups. The frequency of subjects who had the L allele in patients with alcoholic pancreatitis was significantly higher than in other groups. The distribution of the CEL gene polymorphism was not different among the control subjects, alcoholics without pancreatitis, patients with nonalcoholic pancreatitis, and patients with hyperlipidemia. CONCLUSIONS: The CEL gene polymorphism, especially an increase in the frequency of the L allele, was found to be associated with alcohol-induced pancreatitis.
|
Authors | Kyoko Miyasaka, Minoru Ohta, Saeko Takano, Hiroshi Hayashi, Susumu Higuchi, Katsuya Maruyama, Yusuke Tando, Teruo Nakamura, Yutaka Takata, Akihiro Funakoshi |
Journal | Pancreas
(Pancreas)
Vol. 30
Issue 4
Pg. e87-91
(May 2005)
ISSN: 1536-4828 [Electronic] United States |
PMID | 15841033
(Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)
|
Chemical References |
- ALDH2 protein, human
- Aldehyde Dehydrogenase
- Aldehyde Dehydrogenase, Mitochondrial
- Carboxylesterase
|
Topics |
- Aged
- Aldehyde Dehydrogenase
(genetics)
- Aldehyde Dehydrogenase, Mitochondrial
- Alleles
- Carboxylesterase
(genetics)
- Female
- Genetic Predisposition to Disease
(epidemiology)
- Genotype
- Humans
- Hyperlipidemias
(epidemiology, genetics)
- Male
- Middle Aged
- Pancreatitis
(epidemiology, genetics)
- Pancreatitis, Alcoholic
(epidemiology, genetics)
- Polymorphism, Genetic
- Risk Factors
|