Abstract | BACKGROUND: METHODS AND RESULTS: Five patients with chronic ischemic cardiomyopathy caused by anterior myocardial infarction, 1.3+/-0.5 years ago and open infarct artery, received autologous mononuclear BMC transplantation via balloon catheter in the target vessel at the site of previous occlusion. Patients were followed up at 3 months (left heart catheterisation, 2D-echocardiography, dobutamine stress echocardiography, cardiopulmonary exercise testing) and at 12 months (2D-echocardiography, cardiopulmonary exercise testing). Follow-up examination showed no significant improvement neither in global, regional, and microvascular function, nor in physical performance. CONCLUSIONS: In this pilot trial intracoronary transplantation of autologous, mononuclear BMC did not lead to any significant improvement in myocardial function and physical performance of patients with chronic ischemic heart disease.
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Authors | Friedhelm Kuethe, Barbara M Richartz, Christoph Kasper, Herbert G Sayer, Klaus Hoeffken, Gerald S Werner, Hans R Figulla |
Journal | International journal of cardiology
(Int J Cardiol)
Vol. 100
Issue 3
Pg. 485-91
(Apr 28 2005)
ISSN: 0167-5273 [Print] Netherlands |
PMID | 15837094
(Publication Type: Journal Article)
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Topics |
- Adult
- Bone Marrow Transplantation
(methods)
- Catheterization
- Chronic Disease
- Female
- Humans
- Male
- Middle Aged
- Myocardial Ischemia
(surgery)
- Pilot Projects
- Stroke Volume
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