The role of immune reconstitution inflammatory syndrome in AIDS-related Cryptococcus neoformans disease in the era of highly active antiretroviral therapy.

Abstract

This study of human immunodeficiency virus (HIV)-infected patients coinfected with Cryptococcus neoformans found that 30% of patients who initiated highly active antiretroviral therapy developed immune reconstitution inflammatory syndrome (IRIS). Patients with C. neoformans-related IRIS had higher cerebrospinal fluid opening pressures, glucose levels, and white blood cell counts, compared with patients with typical HIV-associated C. neoformans meningitis.

• Authors: Samuel A Shelburne 3rd, Jorge Darcourt, A Clinton White Jr, Stephen B Greenberg, Richard J Hamill, Robert L Atmar, Fehmida Visnegarwala
• Journal: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America (Clin Infect Dis) Vol. 40 Issue 7 Pg. 1049-52 (Apr 01 2005) ISSN: 1537-6591 [Electronic] United States
• PMID: 15825000 (Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)

Chemical References

• Anti-HIV Agents

Topics

• Acquired Immunodeficiency Syndrome (complications)
• Anti-HIV Agents (adverse effects)
• Antiretroviral Therapy, Highly Active (adverse effects)
• Cryptococcosis (etiology)
• Humans
• Inflammation (chemically induced, diagnosis, immunology)
• Recurrence