Abstract | BACKGROUND: METHODS: We enrolled 96 CKD anemic patients on erythropoietin in a randomized, open-label, multicenter, controlled study. Patients received 29 days of oral FeSO4 (325 mg t.i.d.) or intravenous (IV) iron sucrose (5 doses of 200 mg weekly). Assessments were made up to 14 days after the last dose. Primary endpoints were changes in hemoglobin and ferritin, and clinical success was evaluated from the percent of patients with combined endpoints of rises in hemoglobin/ ferritin, hemoglobin/ ferritin/TSAT, and hemoglobin/TSAT. RESULTS: There was no significant difference in hemoglobin values between IV and oral therapy. IV iron patients had greater increases in mean serum ferritin (288 ng/ml, p < 0.0001) compared to oral iron patients (-5.1 ng/ml, p = NS). IV iron patients with baseline ferritin < 100 ng/ml had a greater increase in hemoglobin (1.4 g/dl) compared to oral iron patients (0.9 g/dl) (p < 0.05). More IV iron patients (54.2%) attained hemoglobin values > 11.0 g/dl compared to oral iron patients (31.3%, p = 0.028), and met hemoglobin/ ferritin (62.5%), hemoglobin/TSAT (47.9%), hemoglobin/ ferritin/TSAT (43.8%), and ferritin/TSAT criteria (54.2%) than oral iron patients (0, 22.9, 0, and 0%, respectively). There were no serious side effects. CONCLUSIONS:
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Authors | Chaim Charytan, Wajeh Qunibi, George R Bailie, Venofer Clinical Studies Group |
Journal | Nephron. Clinical practice
(Nephron Clin Pract)
Vol. 100
Issue 3
Pg. c55-62
( 2005)
ISSN: 1660-2110 [Electronic] Switzerland |
PMID | 15824508
(Publication Type: Clinical Trial, Phase II, Clinical Trial, Phase III, Comparative Study, Journal Article, Multicenter Study, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
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Chemical References |
- Hemoglobins
- Sucrose
- Ferritins
- Iron
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Topics |
- Administration, Oral
- Adult
- Aged
- Anemia
(drug therapy)
- Chronic Disease
- Female
- Ferritins
(blood)
- Hemoglobins
(analysis)
- Humans
- Injections, Intravenous
- Iron
(administration & dosage, adverse effects)
- Kidney Diseases
(complications)
- Male
- Middle Aged
- Sucrose
(administration & dosage)
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