[Immunohistochemical characteristics of solitary bone cyst].

Abstract

In order to define the histogenesis of bone solitary cyst it was performed immunohistochemical study of surgical material obtained from 17 patients with the monoclonal antibodies against the following antigens: CD-31 (marker of endotheliocytes), IV type collagen (marker of blood vessel basal membrane), vimentin (marker of connective tissue) and Ki-67 (marker of mitotic cell). The results of the study showed, that solitary bone cyst shouldn't be attributed to the blood-vessel formations and because of its vimentin-positive peculiarity it has connective tissue genesis. At the same time bone cyst shouldn't be considered as tumoral process because it contains low quantity of mitotic cells' markers and the latter appears on the peripheral region of an active cyst, where the regeneration and intensive transformation of bone tissue take place. According to the above-mentioned the solitary cyst of bone should be considered as non-tumor connective-tissue pathology, histogenesis of which shouldn't be related to blood vessels.

• Authors: Z M Topuriia, L A Bekauri, D S Makaridze
• Journal: Georgian medical news (Georgian Med News) Issue 118 Pg. 56-8 (Jan 2005) ISSN: 1512-0112 [Print] Georgia (Republic)
• PMID: 15821329 (Publication Type: Journal Article)

Chemical References

• Ki-67 Antigen
• Platelet Endothelial Cell Adhesion Molecule-1
• Vimentin

Topics

• Bone Cysts (diagnosis, etiology, immunology, pathology, surgery)
• Humans
• Immunohistochemistry
• Ki-67 Antigen (analysis)
• Mitosis
• Morphogenesis
• Platelet Endothelial Cell Adhesion Molecule-1 (analysis)
• Vimentin (analysis)