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Antibodies to hn-RNP protein A1 in systemic lupus erythematosus: clinical association with Raynaud's phenomenon and esophageal dysmotility.

Abstract
Antibodies to recombinant hn-RNP protein A1 were found by ELISA in sera from 26 out of 67 unselected patients with systemic lupus erythematosus. A higher number of anti-A1 positive patients had Raynaud's phenomenon (50% vs 7%) and esophageal dysmotility (42% vs 5%) than the anti-A1 negative patients. All 8 patients with both Raynaud's phenomenon and esophageal dysmotility had a positive anti-A1 assay. No association was found with other clinical findings, nor with disease activity and treatment regimes. Anti-A1 antibodies did not correlate with anti-RNP and anti-Sm antibodies, which were present in 30% and 12% of the anti-A1 positive cases and in 22% and 7% of the anti-A1 negative cases, respectively. Our results indicate that antibodies to hn-RNP protein A1 may be associated with a subset of SLE patients with clinical features overlapping those of progressive systemic sclerosis and quite distinct from the group identified by anti-RNP antibodies.
AuthorsC Montecucco, R Caporali, F Cobianchi, C Negri, G C Astaldi-Ricotti
JournalClinical and experimental rheumatology (Clin Exp Rheumatol) 1992 May-Jun Vol. 10 Issue 3 Pg. 223-7 ISSN: 0392-856X [Print] Italy
PMID1582066 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Antibodies, Antinuclear
  • Autoantigens
  • snRNP Core Proteins
Topics
  • Adolescent
  • Adult
  • Aged
  • Antibodies, Antinuclear (analysis)
  • Autoantigens (immunology)
  • Enzyme-Linked Immunosorbent Assay
  • Esophageal Motility Disorders (immunology)
  • Female
  • Humans
  • Lupus Erythematosus, Systemic (immunology)
  • Male
  • Middle Aged
  • Raynaud Disease (immunology)
  • snRNP Core Proteins

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