Abstract |
Antibodies to recombinant hn-RNP protein A1 were found by ELISA in sera from 26 out of 67 unselected patients with systemic lupus erythematosus. A higher number of anti-A1 positive patients had Raynaud's phenomenon (50% vs 7%) and esophageal dysmotility (42% vs 5%) than the anti-A1 negative patients. All 8 patients with both Raynaud's phenomenon and esophageal dysmotility had a positive anti-A1 assay. No association was found with other clinical findings, nor with disease activity and treatment regimes. Anti-A1 antibodies did not correlate with anti-RNP and anti-Sm antibodies, which were present in 30% and 12% of the anti-A1 positive cases and in 22% and 7% of the anti-A1 negative cases, respectively. Our results indicate that antibodies to hn-RNP protein A1 may be associated with a subset of SLE patients with clinical features overlapping those of progressive systemic sclerosis and quite distinct from the group identified by anti-RNP antibodies.
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Authors | C Montecucco, R Caporali, F Cobianchi, C Negri, G C Astaldi-Ricotti |
Journal | Clinical and experimental rheumatology
(Clin Exp Rheumatol)
1992 May-Jun
Vol. 10
Issue 3
Pg. 223-7
ISSN: 0392-856X [Print] Italy |
PMID | 1582066
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Antibodies, Antinuclear
- Autoantigens
- snRNP Core Proteins
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Topics |
- Adolescent
- Adult
- Aged
- Antibodies, Antinuclear
(analysis)
- Autoantigens
(immunology)
- Enzyme-Linked Immunosorbent Assay
- Esophageal Motility Disorders
(immunology)
- Female
- Humans
- Lupus Erythematosus, Systemic
(immunology)
- Male
- Middle Aged
- Raynaud Disease
(immunology)
- snRNP Core Proteins
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