Glucose transporter-1 expression in urothelial papilloma of the bladder.

Abstract

INTRODUCTION:

Urothelial papilloma should be distinguished from low-grade urothelial carcinoma. We report our experience with glucose transporter-1 (Glut-1) expression in urothelial papilloma.

MATERIALS AND METHODS:

From January 1987 to December 2002, 32 patients with papilloma were diagnosed. Glut-1 protein expression was studied in 32 cases of papilloma and 30 cases of carcinoma. Clinical information was obtained by chart review.

RESULTS:

Mean age was 54.7 years, and the solitary lesion was 78.1%. No case of bladder papilloma expressed Glut-1 protein even in cases of recurrent papilloma. However, 67% of urothelial carcinoma specimens were stained for Glut-1 protein. Two patients developed recurrent papilloma (6.2%), 1 of whom (3.1%) developed an urothelial carcinoma 4 years after diagnosis of papilloma.

CONCLUSIONS:

The study showed that papilloma does not express the Glut-1 protein in contrast to urothelial carcinoma. This distinctive expression pattern of Glut-1 will possibly contribute to differentiate urothelial papilloma from low-grade urothelial carcinoma.

• Authors: Jee-Hyun Lee, Youn-Wha Kim, Sung-Goo Chang
• Journal: Urologia internationalis (Urol Int) Vol. 74 Issue 3 Pg. 268-71 ( 2005) ISSN: 0042-1138 [Print] Switzerland
• PMID: 15812216 (Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright 2005 S. Karger AG, Basel.

Chemical References

• Biomarkers, Tumor
• Glucose Transporter Type 1
• Monosaccharide Transport Proteins
• SLC2A1 protein, human

Topics

• Adult
• Aged
• Aged, 80 and over
• Biomarkers, Tumor (biosynthesis)
• Carcinoma (diagnosis)
• Diagnosis, Differential
• Female
• Follow-Up Studies
• Glucose Transporter Type 1
• Humans
• Immunoenzyme Techniques
• Male
• Middle Aged
• Monosaccharide Transport Proteins (biosynthesis)
• Papilloma (metabolism, pathology)
• Retrospective Studies
• Urinary Bladder Neoplasms (metabolism, pathology)
• Urothelium (metabolism, pathology)