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[Protection of puerarin on the cerebral injury in the rats with acute local ischemia].

AbstractOBJECTIVE:
To study the protection of puerarin on the cerebral injury in the rats with acute local ischemia.
METHOD:
Rat was evaluated model of acute local cerebral ischemia was made by ligating middle cerebral artery. The cerebral damage toxylin and eosin((HE).
RESULT:
The number of died neurons were significantly less in puerarin-treated rats than in the rats with cerebral ischemia (P < 0. 05). Similarly, the cerebral edema were significantly attenuated in the puerarin-treated rats as compared with cerebrally ischemic rats.
CONCLUSION:
Puerarin can prevent the neuron from damage induced by acute cerebral ischemia.
AuthorsHong-Ping Pan, Jia-Zhen Yang, Xiang-Lan Mo, Lu-Li Li, Zhen-Lu Huang, Jing Ye, Jin Huang
JournalZhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica (Zhongguo Zhong Yao Za Zhi) Vol. 30 Issue 6 Pg. 457-9 (Mar 2005) ISSN: 1001-5302 [Print] China
PMID15810455 (Publication Type: English Abstract, Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Isoflavones
  • Neuroprotective Agents
  • Vasodilator Agents
  • puerarin
Topics
  • Animals
  • Brain Ischemia (pathology)
  • Cell Death (drug effects)
  • Cerebral Cortex (pathology)
  • Female
  • Infarction, Middle Cerebral Artery (pathology)
  • Isoflavones (pharmacology)
  • Male
  • Neurons (drug effects)
  • Neuroprotective Agents (pharmacology)
  • Rats
  • Rats, Wistar
  • Vasodilator Agents (pharmacology)

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