Abstract | OBJECTIVE: To study the protection of puerarin on the cerebral injury in the rats with acute local ischemia. METHOD: Rat was evaluated model of acute local cerebral ischemia was made by ligating middle cerebral artery. The cerebral damage toxylin and eosin((HE). RESULT: The number of died neurons were significantly less in puerarin-treated rats than in the rats with cerebral ischemia (P < 0. 05). Similarly, the cerebral edema were significantly attenuated in the puerarin-treated rats as compared with cerebrally ischemic rats. CONCLUSION:
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Authors | Hong-Ping Pan, Jia-Zhen Yang, Xiang-Lan Mo, Lu-Li Li, Zhen-Lu Huang, Jing Ye, Jin Huang |
Journal | Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica
(Zhongguo Zhong Yao Za Zhi)
Vol. 30
Issue 6
Pg. 457-9
(Mar 2005)
ISSN: 1001-5302 [Print] China |
PMID | 15810455
(Publication Type: English Abstract, Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Isoflavones
- Neuroprotective Agents
- Vasodilator Agents
- puerarin
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Topics |
- Animals
- Brain Ischemia
(pathology)
- Cell Death
(drug effects)
- Cerebral Cortex
(pathology)
- Female
- Infarction, Middle Cerebral Artery
(pathology)
- Isoflavones
(pharmacology)
- Male
- Neurons
(drug effects)
- Neuroprotective Agents
(pharmacology)
- Rats
- Rats, Wistar
- Vasodilator Agents
(pharmacology)
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