Desipramine treatment for cocaine dependence in buprenorphine- or methadone-treated patients: baseline urine results as predictor of response.

Abstract

The prognostic importance of baseline urines for cocaine was examined in a randomized, placebo-controlled, twelve-week clinical trial in 165 opioid- and cocaine-dependent patients who were treated with desipramine (DMI) in combination with buprenorphine (BUP) or methadone (Meth). Patients with a cocaine-positive urine at baseline (CU+) had significantly fewer cocaine-free urines than those with a negative urine at baseline (CU-neg). The CU+ patients showed a treatment effect of DMI. This DMI effect was significant in patients maintained on BUP but not on Meth.

• Authors: Thomas Kosten, Mehmet Sofuoglu, James Poling, Kishor Gonsai, Alison Oliveto
• Journal: The American journal on addictions (Am J Addict) 2005 Jan-Feb Vol. 14 Issue 1 Pg. 8-17 ISSN: 1055-0496 [Print] England
• PMID: 15804873 (Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial, Research Support, N.I.H., Extramural, Research Support, U.S. Gov't, Non-P.H.S., Research Support, U.S. Gov't, P.H.S.)

Chemical References

• Adrenergic Uptake Inhibitors
• Dopamine Uptake Inhibitors
• Narcotic Antagonists
• Placebos
• Buprenorphine
• Cocaine
• Desipramine
• Methadone

Topics

• Adrenergic Uptake Inhibitors (therapeutic use)
• Adult
• Buprenorphine (therapeutic use)
• Cocaine (urine)
• Cocaine-Related Disorders (drug therapy, rehabilitation)
• Desipramine (therapeutic use)
• Dopamine Uptake Inhibitors (urine)
• Female
• Humans
• Male
• Methadone (therapeutic use)
• Middle Aged
• Narcotic Antagonists (therapeutic use)
• Placebos
• Predictive Value of Tests
• Prognosis
• Treatment Outcome
• Urinalysis