Desipramine treatment for cocaine dependence in buprenorphine- or methadone-treated patients: baseline urine results as predictor of response.

The prognostic importance of baseline urines for cocaine was examined in a randomized, placebo-controlled, twelve-week clinical trial in 165 opioid- and cocaine-dependent patients who were treated with desipramine (DMI) in combination with buprenorphine (BUP) or methadone (Meth). Patients with a cocaine-positive urine at baseline (CU+) had significantly fewer cocaine-free urines than those with a negative urine at baseline (CU-neg). The CU+ patients showed a treatment effect of DMI. This DMI effect was significant in patients maintained on BUP but not on Meth.
AuthorsThomas Kosten, Mehmet Sofuoglu, James Poling, Kishor Gonsai, Alison Oliveto
JournalThe American journal on addictions / American Academy of Psychiatrists in Alcoholism and Addictions (Am J Addict) 2005 Jan-Feb Vol. 14 Issue 1 Pg. 8-17 ISSN: 1055-0496 [Print] United States
PMID15804873 (Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial, Research Support, N.I.H., Extramural, Research Support, U.S. Gov't, Non-P.H.S., Research Support, U.S. Gov't, P.H.S.)
Chemical References
  • Adrenergic Uptake Inhibitors
  • Dopamine Uptake Inhibitors
  • Narcotic Antagonists
  • Placebos
  • Buprenorphine
  • Cocaine
  • Desipramine
  • Methadone
  • Adrenergic Uptake Inhibitors (therapeutic use)
  • Adult
  • Buprenorphine (therapeutic use)
  • Cocaine (urine)
  • Cocaine-Related Disorders (drug therapy, rehabilitation)
  • Desipramine (therapeutic use)
  • Dopamine Uptake Inhibitors (urine)
  • Female
  • Humans
  • Male
  • Methadone (therapeutic use)
  • Middle Aged
  • Narcotic Antagonists (therapeutic use)
  • Placebos
  • Predictive Value of Tests
  • Prognosis
  • Treatment Outcome
  • Urinalysis

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