Abstract | BACKGROUND: AIM: METHODS: RESULTS: Ten obese children (mean body mass index 30.4) enrolled and completed the trial. Mean alanine aminotransferase and aspartate aminotransferase (AST) improved significantly (P < 0.01) from baseline (184, 114 U/L) to end of treatment (98, 68 U/L). Alanine aminotransferase normalized in 40% and AST normalized in 50% of subjects. Children demonstrated significant improvements in liver fat measured by magnetic resonance spectroscopy (30-23%, P < 0.01); insulin sensitivity measured by quantitative insulin sensitivity check index (0.294-0.310, P < 0.05); and quality of life measured by pediatric quality of life inventory 4.0 (69-81, P < 0.01). CONCLUSION:
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Authors | J B Schwimmer, M S Middleton, R Deutsch, J E Lavine |
Journal | Alimentary pharmacology & therapeutics
(Aliment Pharmacol Ther)
Vol. 21
Issue 7
Pg. 871-9
(Apr 01 2005)
ISSN: 0269-2813 [Print] England |
PMID | 15801922
(Publication Type: Clinical Trial, Clinical Trial, Phase II, Journal Article, Research Support, N.I.H., Extramural, Research Support, U.S. Gov't, P.H.S.)
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Chemical References |
- Blood Glucose
- Hypoglycemic Agents
- Metformin
|
Topics |
- Adolescent
- Blood Glucose
(metabolism)
- Child
- Fatty Liver
(drug therapy)
- Female
- Humans
- Hypoglycemic Agents
(administration & dosage, adverse effects)
- Insulin Resistance
- Male
- Metformin
(administration & dosage, adverse effects)
- Pilot Projects
- Quality of Life
- Treatment Outcome
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