Abstract | OBJECTIVE: METHODS: A subset analysis of 98 children from two identical, multi-site, double-blind, randomized, placebo-controlled trials involving 9 weeks of treatment with atomoxetine or placebo was conducted. Patients met DSM-IV ADHD criteria. ODD was diagnosed with the Diagnostic Interview for Children and Adolescents-IV (DICA-IV; Reich, Weiner, and Herjanic, 1997). ADHD severity was assessed with the ADHD Rating Scale-IV-Parent Version: Investigator Administered and Scored ( ADHD-RS-IV-Parent:lnv; DuPaul, Power, Anastopoulos, and Reid, 1998); the short version of the Conners' Parent Rating Scales-Revised (CPRS-R:S; Conners, 2000); and the Clinical Global Impressions of ADHD Severity (CGI- ADHD-S; Guy, 1976). Clinical response was defined as a > or = 25% reduction in ADHD-RS-IV-Parent:lnv total score. RESULTS:
ADHD-RS-IV-Parent:lnv, CGI- ADHD-S, and three CPRS-R:S subscale scores improved markedly with atomoxetine treatment. However, a decrease in the CPRS-R:S Oppositional subscore for atomoxetine-treated patients was not significantly greater than scores for placebo-treated patients. Clinical response rates were 65.4% in the atomoxetine group, and 36.4% in the placebo group (p = .007). CONCLUSION:
Atomoxetine was effective for the treatment of ADHD in patients with comorbid ODD. It did not significantly reduce the severity of ODD symptoms, and was well tolerated by the patients.
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Authors | S Kaplan, J Heiligenstein, S West, J Busner, D Harder, R Dittmann, C Casat, J F Wernicke |
Journal | Journal of attention disorders
(J Atten Disord)
Vol. 8
Issue 2
Pg. 45-52
(Oct 2004)
ISSN: 1087-0547 [Print] United States |
PMID | 15801334
(Publication Type: Clinical Trial, Journal Article, Multicenter Study, Randomized Controlled Trial)
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Chemical References |
- Propylamines
- Atomoxetine Hydrochloride
- Norepinephrine
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Topics |
- Adolescent
- Atomoxetine Hydrochloride
- Attention Deficit Disorder with Hyperactivity
(complications, diagnosis, drug therapy)
- Attention Deficit and Disruptive Behavior Disorders
(complications, drug therapy)
- Child
- Diagnostic and Statistical Manual of Mental Disorders
- Double-Blind Method
- Female
- Humans
- Male
- Neuropsychological Tests
- Norepinephrine
(metabolism)
- Propylamines
(adverse effects, pharmacology, therapeutic use)
- Single-Blind Method
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