Abstract | BACKGROUND: METHODS: In lipopolysaccharide (LPS)-induced mouse sepsis, we examined the effect of rosiglitazone on LPS-induced overproduction of inflammatory mediators, on the expression of adhesion molecules in renal tubular epithelial cells and on renal function. The mechanism of the protective effect was investigated in vitro using human renal tubular epithelial cells. RESULTS: CONCLUSIONS: These results indicate that pre-treatment with rosiglitazone attenuated the production of TNF-alpha and IL-1beta and reduced adhesion molecule expression in renal tubular epithelial cells of LPS-treated mice. Rosiglitazone has an anti-inflammatory effect in renal tubular epithelial cells through the inhibition of NF-kappaB activation.
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Authors | Sik Lee, Won Kim, Kyung Pyo Kang, Sang-Ok Moon, Mi Jeong Sung, Duk Hoon Kim, Hyung Jin Kim, Sung Kwang Park |
Journal | Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association
(Nephrol Dial Transplant)
Vol. 20
Issue 6
Pg. 1057-65
(Jun 2005)
ISSN: 0931-0509 [Print] England |
PMID | 15797891
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Anti-Inflammatory Agents
- I-kappa B Proteins
- Interleukin-1
- Lipopolysaccharides
- NF-kappa B
- NFKBIA protein, human
- Nfkbia protein, mouse
- Thiazolidinediones
- Tumor Necrosis Factor-alpha
- Vascular Cell Adhesion Molecule-1
- Rosiglitazone
- Intercellular Adhesion Molecule-1
- NF-KappaB Inhibitor alpha
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Topics |
- Animals
- Anti-Inflammatory Agents
(pharmacology)
- Blotting, Western
- Disease Models, Animal
- Epithelial Cells
(drug effects, metabolism)
- I-kappa B Proteins
(blood)
- Immunohistochemistry
- Intercellular Adhesion Molecule-1
(blood)
- Interleukin-1
(blood)
- Kidney Tubules
(cytology, drug effects, metabolism)
- Lipopolysaccharides
(pharmacology)
- Male
- Mice
- Mice, Inbred ICR
- NF-KappaB Inhibitor alpha
- NF-kappa B
(antagonists & inhibitors)
- Rosiglitazone
- Sepsis
(blood, drug therapy, physiopathology)
- Thiazolidinediones
(pharmacology)
- Tumor Necrosis Factor-alpha
(analysis)
- Vascular Cell Adhesion Molecule-1
(blood)
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