Abstract |
Multicentric Castleman disease (MCD) is an uncommon lymphoproliferative disorder for which the best therapeutic option is not yet well established. Immune-related disorders are rare complications of MCD. We report on an MCD case in a 23-year-old patient with extensive abdominal involvement and associated immune hemolytic anemia and Raynaud phenomenon. He was negative for human immunodeficiency virus (HIV) and human herpesvirus-8 (HHV-8). After 8 courses of the anti-CD20 monoclonal antibody ( rituximab), the patient achieved complete remission. Interestingly, Raynaud phenomenon disappeared under treatment and no new hemolytic events occurred. Anti-CD20 antibody treatment could be an attractive therapeutic approach for MCD, mainly when immune-related disorders are associated.
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Authors | Enrique M Ocio, Fermin M Sanchez-Guijo, Maria Diez-Campelo, Cristina Castilla, Oscar J Blanco, Dolores Caballero, Jesus F San Miguel |
Journal | American journal of hematology
(Am J Hematol)
Vol. 78
Issue 4
Pg. 302-5
(Apr 2005)
ISSN: 0361-8609 [Print] United States |
PMID | 15795923
(Publication Type: Case Reports, Journal Article)
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Chemical References |
- Antibodies, Monoclonal
- Antibodies, Monoclonal, Murine-Derived
- Antineoplastic Agents
- Rituximab
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Topics |
- Adult
- Antibodies, Monoclonal
(therapeutic use)
- Antibodies, Monoclonal, Murine-Derived
- Antineoplastic Agents
(therapeutic use)
- Castleman Disease
(diagnostic imaging, drug therapy, pathology)
- Humans
- Lymph Nodes
(diagnostic imaging, pathology)
- Male
- Rituximab
- Tomography, X-Ray Computed
- Treatment Outcome
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