Abstract | OBJECTIVE: METHODS: We determined the complete pattern of integrin expression in three craniopharyngiomas by means of a complementary deoxyribonucleic acid microarray. We quantitatively determined the levels of immunohistochemical expression of the different integrins in a series of 37 cases and the pattern of immunohistochemical expression of 10 extracellular matrix components (acting as integrin ligands) in 7 optical chiasms and 11 pituitary stalks. We also quantitatively (computer-assisted microscopy) determined the levels of immunohistochemical expression of galectin-1, -3, -4, -7, and -8 in 50 adamantinomatous craniopharyngiomas. RESULTS: CONCLUSION: Our data suggest that at least part of the adhesiveness of craniopharyngiomas to the surrounding tissue, such as optical chiasms and pituitary stalks, could be explained by the interactions between alpha(2beta1) integrin expressed by craniopharyngiomas and collagens on the one hand, and vitronectin expressed by the surrounding tissue on the other hand. In addition, a Cox regression analysis has revealed that the levels of galectin-4 contribute significant information toward the delay in recurrence independently of surgical status.
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Authors | Florence Lefranc, Tatjana Mijatovic, Christine Decaestecker, Herbert Kaltner, Sabine André, Jacques Brotchi, Isabelle Salmon, Hans-Joachim Gabius, Robert Kiss |
Journal | Neurosurgery
(Neurosurgery)
Vol. 56
Issue 4
Pg. 763-76
(Apr 2005)
ISSN: 1524-4040 [Electronic] United States |
PMID | 15792515
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Galectins
- Integrins
- RNA, Messenger
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Topics |
- Carotid Artery, Internal
(pathology)
- Cell Adhesion
- Craniopharyngioma
(genetics, pathology, surgery)
- Galectins
(genetics)
- Gene Expression Profiling
- Humans
- Integrins
(genetics)
- Optic Chiasm
(pathology)
- Pituitary Gland
(pathology)
- Pituitary Neoplasms
(genetics, pathology, surgery)
- Prognosis
- RNA, Messenger
(genetics)
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